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10.1111/ijcp.14434

http://scihub22266oqcxt.onion/10.1111/ijcp.14434
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suck abstract from ncbi


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pmid34080261      Int+J+Clin+Pract 2021 ; 75 (9): e14434
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  • Promising effects of atorvastatin on mortality and need for mechanical ventilation in patients with severe COVID-19; a retrospective cohort study #MMPMID34080261
  • Haji Aghajani M; Moradi O; Azhdari Tehrani H; Amini H; Pourheidar E; Hatami F; Rabiei MM; Sistanizad M
  • Int J Clin Pract 2021[Sep]; 75 (9): e14434 PMID34080261show ga
  • PURPOSE: Considering the anti-inflammatory effect of atorvastatin and the role of medical comorbidities such as hypertension and coronary artery disease on the prognosis of the COVID-19 patients, we aimed to assess the effect of atorvastatin add-on therapy on mortality caused by COVID-19. METHODS: We conducted a retrospective cohort study, including patients who were hospitalised with confirmed diagnosis of severe COVID-19. Baseline characteristics and related clinical data of patients were recorded. Clinical outcomes consist of in-hospital mortality, need for invasive mechanical ventilation and hospital length of stay. COX regression analysis models were used to assess the association of independent factors to outcomes. RESULTS: Atorvastatin was administered for 421 of 991 patients. The mean age was 61.640 +/- 17.003 years. Older age, higher prevalence of hypertension and coronary artery disease reported in patients who received atorvastatin. These patients have shorter hospital length of stay (P = .001). Based on COX proportional hazard model, in-hospital use of atorvastatin was associated with decrease in mortality (HR = 0.679, P = .005) and lower need for invasive mechanical ventilation (HR = 0.602, P = .014). CONCLUSIONS: Atorvastatin add-on therapy in patient with severe COVID-19 was associated with lower in-hospital mortality and reduced the risk of need for invasive mechanical ventilation which supports to continue the prescription of the medication.
  • |*COVID-19[MESH]
  • |*Respiration, Artificial[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Atorvastatin/therapeutic use[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]


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