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10.1186/s13052-021-01076-7 http://scihub22266oqcxt.onion/10.1186/s13052-021-01076-7 34078438!8170445!34078438     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ital+J+Pediatr 2021 ; 47 (1): 121 Nephropedia Template TP {{tp|p=34078438|t=2021. Diabetes outbreak during COVID19 lock-down in a prediabetic patient with cystic fibrosis long treated with glargine |pdf=|usr=}}{{34078438}} gab.com Text Diabetes outbreak during COVID19 lock-down in a prediabetic patient with cystic fibrosis long treated with glargine JO: Ital J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=34078438 #FOAvip BACKGROUND: Cystic Fibrosis Related Diabetes (CFRD) is a frequent comorbidity of patients with Cystic Fibrosis (CF). A worsening of clinical conditions appears before CFRD. It has been demonstrated a decline in pulmonary function and nutritional status also in patients with prediabetes. Few trials show that insulin may be beneficial in prediabetic CF patients, to date guidelines do not recommend for this condition. CASE PRESENTATION: We report a case of a patient treated with insulin glargine at 13 years, due to glycemic intolerance, and with Lumacaftor/Ivacaftor at 15 years. A reduction of pulmonary exacerbations was observed after glargine therapy, also confirmed after the starting of Lumacaftor/ Ivacaftor in this patient. Pulmonary function improved only after the first year of glargine therapy, then a deterioration appeared due to the natural history of CF lung damage. During the COVID-19 lockdown, poor adherence to care contributed to diabetes mellitus onset needing high insulin requirements. After two weeks the patient returned to prediabetic condition and his previous dose of glargine. CONCLUSIONS: our case highlights firstly that insulin glargine has contributed to preserve him from further clinical worsening due to prediabetes in the years before pandemic, secondly the negative impact of COVID-19 lockdown on the clinical course of a chronic disease as CF. Twit Text FOAVip Diabetes outbreak during COVID19 lock-down in a prediabetic patient with cystic fibrosis long treated with glargine ????Ital J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=34078438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34078438 #FOAvip English Wikipedia <ref>{{Cite pmid|34078438}}</ref> Diabetes outbreak during COVID19 lock-down in a prediabetic patient with cystic fibrosis long treated with glargine #MMPMID34078438 Rosanio FM; Mozzillo E; Cimbalo C; Casertano A; Sepe A; Raia V; Franzese A; Tosco A Ital J Pediatr 2021[Jun]; 47 (1): 121 PMID34078438show ga BACKGROUND: Cystic Fibrosis Related Diabetes (CFRD) is a frequent comorbidity of patients with Cystic Fibrosis (CF). A worsening of clinical conditions appears before CFRD. It has been demonstrated a decline in pulmonary function and nutritional status also in patients with prediabetes. Few trials show that insulin may be beneficial in prediabetic CF patients, to date guidelines do not recommend for this condition. CASE PRESENTATION: We report a case of a patient treated with insulin glargine at 13 years, due to glycemic intolerance, and with Lumacaftor/Ivacaftor at 15 years. A reduction of pulmonary exacerbations was observed after glargine therapy, also confirmed after the starting of Lumacaftor/ Ivacaftor in this patient. Pulmonary function improved only after the first year of glargine therapy, then a deterioration appeared due to the natural history of CF lung damage. During the COVID-19 lockdown, poor adherence to care contributed to diabetes mellitus onset needing high insulin requirements. After two weeks the patient returned to prediabetic condition and his previous dose of glargine. CONCLUSIONS: our case highlights firstly that insulin glargine has contributed to preserve him from further clinical worsening due to prediabetes in the years before pandemic, secondly the negative impact of COVID-19 lockdown on the clinical course of a chronic disease as CF. |Adolescent[MESH] |COVID-19/*epidemiology[MESH] |Cystic Fibrosis/*complications/physiopathology[MESH] |Diabetes Mellitus, Type 1/*complications/*drug therapy[MESH] |Humans[MESH] |Hypoglycemic Agents/*therapeutic use[MESH] |Insulin Glargine/*therapeutic use[MESH] |Male[MESH] |Pandemics[MESH] |Prediabetic State[MESH] |Respiratory Function Tests[MESH]Diabetes outbreak during COVID19 lock-down in a prediabetic patient wi(epmc).pdf DeepDyve Pubget Overpricing