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10.1128/JCM.00569-21 http://scihub22266oqcxt.onion/10.1128/JCM.00569-21 34076471!8373031!34076471     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Microbiol 2021 ; 59 (9): e0056921 Nephropedia Template TP {{tp|p=34076471|t=2021. Nasal Swab Performance by Collection Timing, Procedure, and Method of Transport for Patients with SARS-CoV-2 |pdf=|usr=}}{{34076471}} gab.com Text Nasal Swab Performance by Collection Timing, Procedure, and Method of Transport for Patients with SARS-CoV-2 JO: J Clin Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34076471 #FOAvip The urgent need for large-scale diagnostic testing for SARS-CoV-2 has prompted interest in sample collection methods of sufficient sensitivity to replace nasopharynx (NP) sampling. Nasal swab samples are an attractive alternative; however, previous studies have disagreed over how nasal sampling performs relative to NP sampling. Here, we compared nasal versus NP specimens collected by health care workers in a cohort of individuals clinically suspected of COVID-19 as well as SARS-CoV-2 reverse transcription (RT)-PCR-positive outpatients undergoing follow-up. We compared subjects being seen for initial evaluation versus follow-up, two different nasal swab collection protocols, and three different transport conditions, including traditional viral transport media (VTM) and dry swabs, on 307 total study participants. We compared categorical results and viral loads to those from standard NP swabs collected at the same time from the same patients. All testing was performed by RT-PCR on the Abbott SARS-CoV-2 RealTime emergency use authorization (EUA) (limit of detection [LoD], 100 copies viral genomic RNA/ml transport medium). We found low concordance overall, with Cohen's kappa (kappa) of 0.49, with high concordance only for subjects with very high viral loads. We found medium concordance for testing at initial presentation (kappa = 0.68) and very low concordance for follow-up testing (kappa = 0.27). Finally, we show that previous reports of high concordance may have resulted from measurement using assays with sensitivity of >/=1,000 copies/ml. These findings suggest nasal-swab testing be used for situations in which viral load is expected to be high, as we demonstrate that nasal swab testing is likely to miss patients with low viral loads. Twit Text FOAVip Nasal Swab Performance by Collection Timing, Procedure, and Method of Transport for Patients with SARS-CoV-2 ????J Clin Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34076471 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34076471 #FOAvip English Wikipedia <ref>{{Cite pmid|34076471}}</ref> Nasal Swab Performance by Collection Timing, Procedure, and Method of Transport for Patients with SARS-CoV-2 #MMPMID34076471 Callahan C; Lee RA; Lee GR; Zulauf K; Kirby JE; Arnaout R J Clin Microbiol 2021[Aug]; 59 (9): e0056921 PMID34076471show ga The urgent need for large-scale diagnostic testing for SARS-CoV-2 has prompted interest in sample collection methods of sufficient sensitivity to replace nasopharynx (NP) sampling. Nasal swab samples are an attractive alternative; however, previous studies have disagreed over how nasal sampling performs relative to NP sampling. Here, we compared nasal versus NP specimens collected by health care workers in a cohort of individuals clinically suspected of COVID-19 as well as SARS-CoV-2 reverse transcription (RT)-PCR-positive outpatients undergoing follow-up. We compared subjects being seen for initial evaluation versus follow-up, two different nasal swab collection protocols, and three different transport conditions, including traditional viral transport media (VTM) and dry swabs, on 307 total study participants. We compared categorical results and viral loads to those from standard NP swabs collected at the same time from the same patients. All testing was performed by RT-PCR on the Abbott SARS-CoV-2 RealTime emergency use authorization (EUA) (limit of detection [LoD], 100 copies viral genomic RNA/ml transport medium). We found low concordance overall, with Cohen's kappa (kappa) of 0.49, with high concordance only for subjects with very high viral loads. We found medium concordance for testing at initial presentation (kappa = 0.68) and very low concordance for follow-up testing (kappa = 0.27). Finally, we show that previous reports of high concordance may have resulted from measurement using assays with sensitivity of >/=1,000 copies/ml. These findings suggest nasal-swab testing be used for situations in which viral load is expected to be high, as we demonstrate that nasal swab testing is likely to miss patients with low viral loads. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Diagnostic Tests, Routine[MESH] |Humans[MESH] |Nasopharynx[MESH]Nasal Swab Performance by Collection Timing, Procedure, and Method of (epmc).pdf DeepDyve Pubget Overpricing