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10.1007/s12035-021-02438-2

http://scihub22266oqcxt.onion/10.1007/s12035-021-02438-2
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34075562!8169418!34075562
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suck abstract from ncbi


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pmid34075562      Mol+Neurobiol 2021 ; 58 (8): 4178-4187
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  • The Effect of COVID-19 on NF-kappaB and Neurological Manifestations of Disease #MMPMID34075562
  • Davies DA; Adlimoghaddam A; Albensi BC
  • Mol Neurobiol 2021[Aug]; 58 (8): 4178-4187 PMID34075562show ga
  • The coronavirus disease that presumably began in 2019 (COVID-19) is a highly infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic. Initially, COVID-19 was thought to only affect respiration. However, accumulating evidence shows a wide range of neurological symptoms are also associated with COVID-19, such as anosmia/ageusia, headaches, seizures, demyelination, mental confusion, delirium, and coma. Neurological symptoms in COVID-19 patients may arise due to a cytokine storm and a heighten state of inflammation. The nuclear factor kappa-light-chain enhancer of activated B cells (NF-kappaB) is a central pathway involved with inflammation and is shown to be elevated in a dose-dependent matter in response to coronaviruses. NF-kappaB has a role in cytokine storm syndrome, which is associated with greater severity in COVID-19-related symptoms. Therefore, therapeutics that reduce the NF-kappaB pathway should be considered in the treatment of COVID-19. Neuro-COVID-19 units have been established across the world to examine the neurological symptoms associated with COVID-19. Neuro-COVID-19 is increasingly becoming an accepted term among scientists and clinicians, and interdisciplinary teams should be created to implement strategies for treating the wide range of neurological symptoms observed in COVID-19 patients.
  • |Brain/pathology/virology[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*complications/*metabolism/virology[MESH]
  • |Humans[MESH]
  • |Inflammation/pathology[MESH]
  • |NF-kappa B/*metabolism[MESH]
  • |Nervous System Diseases/*virology[MESH]


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