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10.1093/jac/dkab190 http://scihub22266oqcxt.onion/10.1093/jac/dkab190 34075390!8195206!34075390     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Antimicrob+Chemother 2021 ; 76 (9): 2234-2236 Nephropedia Template TP {{tp|p=34075390|t=2021. Clinical trials during pandemics and beyond: time for a more efficient pharmacological strategy |pdf=|usr=}}{{34075390}} gab.com Text Clinical trials during pandemics and beyond: time for a more efficient pharmacological strategy JO: J Antimicrob Chemother http://www.kidney.de/pget.php?&tw=1&pmid=34075390 #FOAvip During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, clinical trials on antiviral or symptomatic drugs have been conducted very rapidly even for drugs with a poor pharmacological rationale for efficacy on SARS-CoV-2. Despite lacking basic pharmacological information, most of these clinical trials were also extremely redundant. Applying simple rules, (such as identifying a mechanistic rationale, confirming the ability to reach exposure targets at therapeutic dosage and ensuring tests show drug efficacy in appropriate in vitro and animal models before entering clinical trials) might have saved considerable amounts of time and money, and might have avoided useless research. Moreover, combining these simple rules with the implementation of a relevant policy at both an international and a national level, by limiting studies with a poor methodological/scientific approach and aggregating studies with similar design into single clinical trials, is potentially a far more-efficient strategy. Twit Text FOAVip Clinical trials during pandemics and beyond: time for a more efficient pharmacological strategy ????J Antimicrob Chemother http://www.kidney.de/pget.php?&tw=1&pmid=34075390 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34075390 #FOAvip English Wikipedia <ref>{{Cite pmid|34075390}}</ref> Clinical trials during pandemics and beyond: time for a more efficient pharmacological strategy #MMPMID34075390 Lemaitre F; Locher C; Verdier MC; Naudet F J Antimicrob Chemother 2021[Aug]; 76 (9): 2234-2236 PMID34075390show ga During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, clinical trials on antiviral or symptomatic drugs have been conducted very rapidly even for drugs with a poor pharmacological rationale for efficacy on SARS-CoV-2. Despite lacking basic pharmacological information, most of these clinical trials were also extremely redundant. Applying simple rules, (such as identifying a mechanistic rationale, confirming the ability to reach exposure targets at therapeutic dosage and ensuring tests show drug efficacy in appropriate in vitro and animal models before entering clinical trials) might have saved considerable amounts of time and money, and might have avoided useless research. Moreover, combining these simple rules with the implementation of a relevant policy at both an international and a national level, by limiting studies with a poor methodological/scientific approach and aggregating studies with similar design into single clinical trials, is potentially a far more-efficient strategy. |*COVID-19[MESH] |*Pandemics[MESH] |Animals[MESH] |Antiviral Agents/pharmacology/therapeutic use[MESH] |Clinical Trials as Topic[MESH] |Humans[MESH]Clinical trials during pandemics and beyond: time for a more efficient(epmc).pdf DeepDyve Pubget Overpricing