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10.1101/2021.05.26.445787 http://scihub22266oqcxt.onion/10.1101/2021.05.26.445787 34075374!8168382!34075374     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       bioRxiv 2021 ; ä (ä): ä Nephropedia Template TP {{tp|p=34075374|t=2021. SARS-CoV-2 Nsp14 activates NF-kappaB signaling and induces IL-8 upregulation |pdf=|usr=}}{{34075374}} gab.com Text SARS-CoV-2 Nsp14 activates NF-kappaB signaling and induces IL-8 upregulation JO: bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=34075374 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-kappaB activation and induction of pro-inflammatory cytokines, though the underlying mechanism for this activation is not fully understood. Our results reveal that the SARS-CoV-2 Nsp14 protein contributes to the viral activation of NF-kappaB signaling. Nsp14 caused the nuclear translocation of NF-kappaB p65. Nsp14 induced the upregulation of IL-6 and IL-8, which also occurred in SARS-CoV-2 infected cells. IL-8 upregulation was further confirmed in lung tissue samples from COVID-19 patients. A previous proteomic screen identified the putative interaction of Nsp14 with host Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) protein, which is known to regulate NF-kappaB signaling. We confirmed the Nsp14-IMPDH2 protein interaction and found that IMPDH2 knockdown or chemical inhibition using ribavirin (RIB) and mycophenolic acid (MPA) abolishes Nsp14-mediated NF-kappaB activation and cytokine induction. Furthermore, IMDPH2 inhibitors (RIB, MPA) efficiently blocked SARS-CoV-2 infection, indicating that IMDPH2, and possibly NF-kappaB signaling, is beneficial to viral replication. Overall, our results identify a novel role of SARS-CoV-2 Nsp14 in causing the activation of NF-kappaB. Twit Text FOAVip SARS-CoV-2 Nsp14 activates NF-kappaB signaling and induces IL-8 upregulation ????bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=34075374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34075374 #FOAvip English Wikipedia <ref>{{Cite pmid|34075374}}</ref> SARS-CoV-2 Nsp14 activates NF-kappaB signaling and induces IL-8 upregulation #MMPMID34075374 Li T; Kenney AD; Liu H; Fiches GN; Zhou D; Biswas A; Que J; Santoso N; Yount JS; Zhu J bioRxiv 2021[May]; ä (ä): ä PMID34075374show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-kappaB activation and induction of pro-inflammatory cytokines, though the underlying mechanism for this activation is not fully understood. Our results reveal that the SARS-CoV-2 Nsp14 protein contributes to the viral activation of NF-kappaB signaling. Nsp14 caused the nuclear translocation of NF-kappaB p65. Nsp14 induced the upregulation of IL-6 and IL-8, which also occurred in SARS-CoV-2 infected cells. IL-8 upregulation was further confirmed in lung tissue samples from COVID-19 patients. A previous proteomic screen identified the putative interaction of Nsp14 with host Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) protein, which is known to regulate NF-kappaB signaling. We confirmed the Nsp14-IMPDH2 protein interaction and found that IMPDH2 knockdown or chemical inhibition using ribavirin (RIB) and mycophenolic acid (MPA) abolishes Nsp14-mediated NF-kappaB activation and cytokine induction. Furthermore, IMDPH2 inhibitors (RIB, MPA) efficiently blocked SARS-CoV-2 infection, indicating that IMDPH2, and possibly NF-kappaB signaling, is beneficial to viral replication. Overall, our results identify a novel role of SARS-CoV-2 Nsp14 in causing the activation of NF-kappaB. äSARS-CoV-2 Nsp14 activates NF-kappaB signaling and induces IL-8 upregu(epmc).pdf DeepDyve Pubget Overpricing