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10.1016/j.xcrm.2021.100321

http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100321
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suck abstract from ncbi


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pmid34075365      Cell+Rep+Med 2021 ; 2 (6): 100321
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  • Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19 #MMPMID34075365
  • Wong AKH; Woodhouse I; Schneider F; Kulpa DA; Silvestri G; Maier CL
  • Cell Rep Med 2021[Jun]; 2 (6): 100321 PMID34075365show ga
  • The pathogenesis of severe coronavirus disease 2019 (COVID-19) remains poorly understood. While several studies suggest that immune dysregulation plays a central role, the key mediators of this process are yet to be defined. Here, we demonstrate that plasma from a high proportion (93%) of critically ill COVID-19 patients, but not healthy controls, contains broadly auto-reactive immunoglobulin M (IgM) and less frequently auto-reactive IgG or IgA. Importantly, these auto-IgMs preferentially recognize primary human lung cells in vitro, including pulmonary endothelial and epithelial cells. By using a combination of flow cytometry, analytical proteome microarray technology, and lactose dehydrogenase (LDH)-release cytotoxicity assays, we identify high-affinity, complement-fixing, auto-reactive IgM directed against 260 candidate autoantigens, including numerous molecules preferentially expressed on the cellular membranes of pulmonary, vascular, gastrointestinal, and renal tissues. These findings suggest that broad IgM-mediated autoimmune reactivity may be involved in the pathogenesis of severe COVID-19, thereby identifying a potential target for therapeutic interventions.
  • |Autoantibodies/blood/*immunology[MESH]
  • |COVID-19/immunology/*pathology/virology[MESH]
  • |Cell Line[MESH]
  • |Complement C4/metabolism[MESH]
  • |Critical Illness[MESH]
  • |Humans[MESH]
  • |Immunoglobulin M/blood/*immunology[MESH]
  • |Intensive Care Units[MESH]
  • |Lung/metabolism[MESH]
  • |Protein Array Analysis[MESH]
  • |Proteome/analysis[MESH]


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