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10.1016/j.xcrm.2021.100321 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100321 34075365!8160082!34075365     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34075365&cmd=llinks): Failed to open stream: HTTP request failed! 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Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19 |pdf=|usr=}}{{34075365}} gab.com Text Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19 JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34075365 #FOAvip The pathogenesis of severe coronavirus disease 2019 (COVID-19) remains poorly understood. While several studies suggest that immune dysregulation plays a central role, the key mediators of this process are yet to be defined. Here, we demonstrate that plasma from a high proportion (93%) of critically ill COVID-19 patients, but not healthy controls, contains broadly auto-reactive immunoglobulin M (IgM) and less frequently auto-reactive IgG or IgA. Importantly, these auto-IgMs preferentially recognize primary human lung cells in vitro, including pulmonary endothelial and epithelial cells. By using a combination of flow cytometry, analytical proteome microarray technology, and lactose dehydrogenase (LDH)-release cytotoxicity assays, we identify high-affinity, complement-fixing, auto-reactive IgM directed against 260 candidate autoantigens, including numerous molecules preferentially expressed on the cellular membranes of pulmonary, vascular, gastrointestinal, and renal tissues. These findings suggest that broad IgM-mediated autoimmune reactivity may be involved in the pathogenesis of severe COVID-19, thereby identifying a potential target for therapeutic interventions. Twit Text FOAVip Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19 ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34075365 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34075365 #FOAvip English Wikipedia <ref>{{Cite pmid|34075365}}</ref> Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19 #MMPMID34075365 Wong AKH; Woodhouse I; Schneider F; Kulpa DA; Silvestri G; Maier CL Cell Rep Med 2021[Jun]; 2 (6): 100321 PMID34075365show ga The pathogenesis of severe coronavirus disease 2019 (COVID-19) remains poorly understood. While several studies suggest that immune dysregulation plays a central role, the key mediators of this process are yet to be defined. Here, we demonstrate that plasma from a high proportion (93%) of critically ill COVID-19 patients, but not healthy controls, contains broadly auto-reactive immunoglobulin M (IgM) and less frequently auto-reactive IgG or IgA. Importantly, these auto-IgMs preferentially recognize primary human lung cells in vitro, including pulmonary endothelial and epithelial cells. By using a combination of flow cytometry, analytical proteome microarray technology, and lactose dehydrogenase (LDH)-release cytotoxicity assays, we identify high-affinity, complement-fixing, auto-reactive IgM directed against 260 candidate autoantigens, including numerous molecules preferentially expressed on the cellular membranes of pulmonary, vascular, gastrointestinal, and renal tissues. These findings suggest that broad IgM-mediated autoimmune reactivity may be involved in the pathogenesis of severe COVID-19, thereby identifying a potential target for therapeutic interventions. |Autoantibodies/blood/*immunology[MESH] |COVID-19/immunology/*pathology/virology[MESH] |Cell Line[MESH] |Complement C4/metabolism[MESH] |Critical Illness[MESH] |Humans[MESH] |Immunoglobulin M/blood/*immunology[MESH] |Intensive Care Units[MESH] |Lung/metabolism[MESH] |Protein Array Analysis[MESH] |Proteome/analysis[MESH]Broad auto-reactive IgM responses are common in critically ill patient(epmc).pdf DeepDyve Pubget Overpricing