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10.1016/j.heliyon.2021.e07147 http://scihub22266oqcxt.onion/10.1016/j.heliyon.2021.e07147 34075347!8159709!34075347     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Heliyon 2021 ; 7 (6): e07147 Nephropedia Template TP {{tp|p=34075347|t=2021. SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells |pdf=|usr=}}{{34075347}} gab.com Text SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells JO: Heliyon http://www.kidney.de/pget.php?&tw=1&pmid=34075347 #FOAvip The SARS-CoV-2 virus is the causative agent of the global COVID-19 infectious disease outbreak, which can lead to acute respiratory distress syndrome (ARDS). However, it is still unclear how the virus interferes with immune cell and metabolic functions in the human body. In this study, we investigated the immune response in acute or convalescent COVID-19 patients. We characterized the peripheral blood mononuclear cells (PBMCs) using flow cytometry and found that CD8(+) T cells were significantly subsided in moderate COVID-19 and convalescent patients. Furthermore, characterization of CD8(+) T cells suggested that convalescent patients have significantly diminished expression of both perforin and granzyme A. Using (1)H-NMR spectroscopy, we characterized the metabolic status of their autologous PBMCs. We found that fructose, lactate and taurine levels were elevated in infected (mild and moderate) patients compared with control and convalescent patients. Glucose, glutamate, formate and acetate levels were attenuated in COVID-19 (mild and moderate) patients. In summary, our report suggests that SARS-CoV-2 infection leads to disrupted CD8(+) T cytotoxic functions and changes the overall metabolic functions of immune cells. Twit Text FOAVip SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells ????Heliyon http://www.kidney.de/pget.php?&tw=1&pmid=34075347 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34075347 #FOAvip English Wikipedia <ref>{{Cite pmid|34075347}}</ref> SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells #MMPMID34075347 Singh Y; Trautwein C; Fendel R; Krickeberg N; Berezhnoy G; Bissinger R; Ossowski S; Salker MS; Casadei N; Riess O Heliyon 2021[Jun]; 7 (6): e07147 PMID34075347show ga The SARS-CoV-2 virus is the causative agent of the global COVID-19 infectious disease outbreak, which can lead to acute respiratory distress syndrome (ARDS). However, it is still unclear how the virus interferes with immune cell and metabolic functions in the human body. In this study, we investigated the immune response in acute or convalescent COVID-19 patients. We characterized the peripheral blood mononuclear cells (PBMCs) using flow cytometry and found that CD8(+) T cells were significantly subsided in moderate COVID-19 and convalescent patients. Furthermore, characterization of CD8(+) T cells suggested that convalescent patients have significantly diminished expression of both perforin and granzyme A. Using (1)H-NMR spectroscopy, we characterized the metabolic status of their autologous PBMCs. We found that fructose, lactate and taurine levels were elevated in infected (mild and moderate) patients compared with control and convalescent patients. Glucose, glutamate, formate and acetate levels were attenuated in COVID-19 (mild and moderate) patients. In summary, our report suggests that SARS-CoV-2 infection leads to disrupted CD8(+) T cytotoxic functions and changes the overall metabolic functions of immune cells. äSARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of th(epmc).pdf DeepDyve Pubget Overpricing