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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Cent+Sci 2021 ; 7 (5): 748-756 Nephropedia Template TP
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Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines #MMPMID34075344
Nance KD; Meier JL
ACS Cent Sci 2021[May]; 7 (5): 748-756 PMID34075344show ga
The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history. A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase N1-methylpseudouridine (m1Psi) to increase their effectiveness. In this Outlook, we summarize the development and function of m1Psi in synthetic mRNAs. By demystifying how a novel element within these medicines works, we aim to foster understanding and highlight future opportunities for chemical innovation.