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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Medicine+(Madr) 2021 ; 13 (33): 1917-1931 Nephropedia Template TP
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Papel del sistema inmune en la infeccion por el SARS-CoV-2: inmunopatologia de la COVID-19 #MMPMID34075268
Sanz JM; Gomez Lahoz AM; Martin RO
Medicine (Madr) 2021[May]; 13 (33): 1917-1931 PMID34075268show ga
The immune system is capable of adequately controlling SARS-CoV-2 infection in 81% of patients, whose disease is asymptomatic or who experience moderate symptoms. However, 19% of infected patients develop severe disease which can become critical or fatal. This review article intends to provide an overview of the epidemiological antecedents of beta-coronaviruses, describe the mechanisms of SARS-CoV-2 infection, and summarize the rational immunological underpinnings known at present which allow for a better understanding of the immunopathology of COVID-19. The SARS-CoV-2 virus is capable of profoundly altering the behavior of molecular and cellular components of the immune system. The initial decisions of the innate immune system are responsible for a proper or improper response of the adaptive immune system and, along with comorbidities, are directly associated with disease progression.