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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Transplant 2021 ; 30 (ä): 9636897211021008 Nephropedia Template TP
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Combined Use of Tocilizumab and Mesenchymal Stromal Cells in the Treatment of Severe Covid-19: Case Report #MMPMID34074163
Senegaglia AC; Rebelatto CLK; Franck CL; Lima JS; Boldrini-Leite LM; Daga DR; Leitao CA; Shigunov P; de Azambuja AP; Bana E; Marsaro DB; Schaidt B; Micosky A; Jamur VR; Schluga Y; Vaz IM; Ribeiro LL; Correa A; Brofman EPRS
Cell Transplant 2021[Jan]; 30 (ä): 9636897211021008 PMID34074163show ga
The coronavirus pandemic is one of the most significant public health events in recent history. Currently, no specific treatment is available. Some drugs and cell-based therapy have been tested as alternatives to decrease the disease's symptoms, length of hospital stay, and mortality. We reported the case of a patient with a severe manifestation of COVID-19 in critical condition who did not respond to the standard procedures used, including six liters of O(2) supplementation under a nasal catheter and treatment with dexamethasone and enoxaparin in prophylactic dose. The patient was treated with tocilizumab and an advanced therapy product based on umbilical cord-derived mesenchymal stromal cells (UC-MSC). The combination of tocilizumab and UC-MSC proved to be safe, with no adverse effects, and the results of this case report prove to be a promising alternative in the treatment of patients with severe acute respiratory syndrome due to SARS-CoV-2.