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10.3390/biom11060796 http://scihub22266oqcxt.onion/10.3390/biom11060796 34073591!8226817!34073591     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34073591&cmd=llinks): Failed to open stream: HTTP request failed! 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Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia |pdf=|usr=}}{{34073591}} gab.com Text Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=34073591 #FOAvip Angiotensin-converting enzyme 2 (ACE-2) is the main cell entry receptor for severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2), thus playing a critical role in causing Coronavirus disease 2019 (COVID-19). The role of smoking habit in the susceptibility to infection is still controversial. In this study we correlated lung ACE-2 gene expression with several clinical/pathological data to explore susceptibility to infection. This is a retrospective observational study on 29 consecutive COVID-19 autopsies. SARS-CoV-2 genome and ACE-2 mRNA expression were evaluated by real-time polymerase chain reaction in lung tissue samples and correlated with several data with focus on smoking habit. Smoking was less frequent in high than low ACE-2 expressors (p = 0.014). A Bayesian regression also including age, gender, hypertension, and virus quantity confirmed that smoking was the most probable risk factor associated with low ACE-2 expression in the model. A direct relation was found between viral quantity and ACE-2 expression (p = 0.028). Finally, high ACE-2 expressors more frequently showed a prevalent pattern of vascular injury than low expressors (p = 0.049). In conclusion, ACE-2 levels were decreased in the lung tissue of smokers with severe COVID-19 pneumonia. These results point out complex biological interactions between SARS-CoV-2 and ACE-2 particularly concerning the aspect of smoking habit and need larger prospective case series and translational studies. Twit Text FOAVip Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=34073591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34073591 #FOAvip English Wikipedia <ref>{{Cite pmid|34073591}}</ref> Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia #MMPMID34073591 Lunardi F; Fortarezza F; Vedovelli L; Pezzuto F; Boscolo A; Rossato M; Vettor R; Cattelan AM; Del Vecchio C; Crisanti A; Navalesi P; Gregori D; Calabrese F Biomolecules 2021[May]; 11 (6): ä PMID34073591show ga Angiotensin-converting enzyme 2 (ACE-2) is the main cell entry receptor for severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2), thus playing a critical role in causing Coronavirus disease 2019 (COVID-19). The role of smoking habit in the susceptibility to infection is still controversial. In this study we correlated lung ACE-2 gene expression with several clinical/pathological data to explore susceptibility to infection. This is a retrospective observational study on 29 consecutive COVID-19 autopsies. SARS-CoV-2 genome and ACE-2 mRNA expression were evaluated by real-time polymerase chain reaction in lung tissue samples and correlated with several data with focus on smoking habit. Smoking was less frequent in high than low ACE-2 expressors (p = 0.014). A Bayesian regression also including age, gender, hypertension, and virus quantity confirmed that smoking was the most probable risk factor associated with low ACE-2 expression in the model. A direct relation was found between viral quantity and ACE-2 expression (p = 0.028). Finally, high ACE-2 expressors more frequently showed a prevalent pattern of vascular injury than low expressors (p = 0.049). In conclusion, ACE-2 levels were decreased in the lung tissue of smokers with severe COVID-19 pneumonia. These results point out complex biological interactions between SARS-CoV-2 and ACE-2 particularly concerning the aspect of smoking habit and need larger prospective case series and translational studies. |Aged[MESH] |Aged, 80 and over[MESH] |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH] |Bayes Theorem[MESH] |COVID-19/*pathology/virology[MESH] |Female[MESH] |Humans[MESH] |Lung/*metabolism/pathology[MESH] |Male[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |SARS-CoV-2/isolation & purification[MESH]Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in L(epmc).pdf DeepDyve Pubget Overpricing