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10.3390/ijms22115676

http://scihub22266oqcxt.onion/10.3390/ijms22115676
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34073578!8197834!34073578
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suck abstract from ncbi

pmid34073578      Int+J+Mol+Sci 2021 ; 22 (11): ä
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  • Ceramide and Related Molecules in Viral Infections #MMPMID34073578
  • Beckmann N; Becker KA
  • Int J Mol Sci 2021[May]; 22 (11): ä PMID34073578show ga
  • Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the physical properties of biological membranes, including the formation of membrane microdomains. Thus, ceramide and its related molecules have been attributed significant roles in nearly all steps of the viral life cycle: they may serve directly as receptors or co-receptors for viral entry, form microdomains that cluster entry receptors and/or enable them to adopt the required conformation or regulate their cell surface expression. Sphingolipids can regulate all forms of viral uptake, often through sphingomyelinase activation, and mediate endosomal escape and intracellular trafficking. Ceramide can be key for the formation of viral replication sites. Sphingomyelinases often mediate the release of new virions from infected cells. Moreover, sphingolipids can contribute to viral-induced apoptosis and morbidity in viral diseases, as well as virus immune evasion. Alpha-galactosylceramide, in particular, also plays a significant role in immune modulation in response to viral infections. This review will discuss the roles of ceramide and its related molecules in the different steps of the viral life cycle. We will also discuss how novel strategies could exploit these for therapeutic benefit.
  • |Apoptosis/drug effects/immunology[MESH]
  • |Ceramides/chemistry/*metabolism[MESH]
  • |Gene Expression Regulation, Viral[MESH]
  • |HIV-1/*metabolism/pathogenicity[MESH]
  • |Humans[MESH]
  • |Immunomodulation[MESH]
  • |Influenza A virus/*metabolism/pathogenicity[MESH]
  • |SARS-CoV-2/*metabolism/pathogenicity[MESH]
  • |Virion/growth & development[MESH]
  • |Virus Diseases/immunology/*metabolism/*virology[MESH]
  • |Virus Internalization[MESH]


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