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10.3390/v13060996

http://scihub22266oqcxt.onion/10.3390/v13060996
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34073577!8229637!34073577
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suck abstract from ncbi


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pmid34073577      Viruses 2021 ; 13 (6): ä
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  • Kinetics of Neutralizing Antibodies of COVID-19 Patients Tested Using Clinical D614G, B 1 1 7, and B 1 351 Isolates in Microneutralization Assays #MMPMID34073577
  • Virtanen J; Uusitalo R; Korhonen EM; Aaltonen K; Smura T; Kuivanen S; Pakkanen SH; Mero S; Patjas A; Riekkinen M; Kantele A; Nurmi V; Hedman K; Hepojoki J; Sironen T; Huhtamo E; Vapalahti O
  • Viruses 2021[May]; 13 (6): ä PMID34073577show ga
  • Increasing evidence suggests that some newly emerged SARS-CoV-2 variants of concern (VoCs) resist neutralization by antibodies elicited by the early-pandemic wild-type virus. We applied neutralization tests to paired recoveree sera (n = 38) using clinical isolates representing the first wave (D614G), VoC1, and VoC2 lineages (B.1.1.7 and B 1.351). Neutralizing antibodies inhibited contemporary and VoC1 lineages, whereas inhibition of VoC2 was reduced 8-fold, with 50% of sera failing to show neutralization. These results provide evidence for the increased potential of VoC2 to reinfect previously SARS-CoV-infected individuals. The kinetics of NAbs in different patients showed similar decline against all variants, with generally low initial anti-B.1.351 responses becoming undetectable, but with anti-B.1.1.7 NAbs remaining detectable (>20) for months after acute infection.
  • |Animals[MESH]
  • |Antibodies, Neutralizing/*immunology[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |COVID-19/diagnosis/*immunology/virology[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Coronavirus Nucleocapsid Proteins/immunology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/immunology[MESH]
  • |Kinetics[MESH]
  • |Neutralization Tests[MESH]
  • |Phosphoproteins/immunology[MESH]
  • |SARS-CoV-2/genetics/*immunology/isolation & purification[MESH]
  • |Severity of Illness Index[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]


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