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10.3390/biomedicines9060602

http://scihub22266oqcxt.onion/10.3390/biomedicines9060602
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34073231!8226796!34073231
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suck abstract from ncbi


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pmid34073231      Biomedicines 2021 ; 9 (6): ä
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  • 3D Cell Culture Models in COVID-19 Times: A Review of 3D Technologies to Understand and Accelerate Therapeutic Drug Discovery #MMPMID34073231
  • de Dios-Figueroa GT; Aguilera-Marquez JDR; Camacho-Villegas TA; Lugo-Fabres PH
  • Biomedicines 2021[May]; 9 (6): ä PMID34073231show ga
  • In the last decades, emerging viruses have become a worldwide concern. The fast and extensive spread of the disease caused by SARS-CoV-2 (COVID-19) has impacted the economy and human activity worldwide, highlighting the human vulnerability to infectious diseases and the need to develop and optimize technologies to tackle them. The three-dimensional (3D) cell culture models emulate major tissue characteristics such as the in vivo virus-host interactions. These systems may help to generate a quick response to confront new viruses, establish a reliable evaluation of the pathophysiology, and contribute to therapeutic drug evaluation in pandemic situations such as the one that humanity is living through today. This review describes different types of 3D cell culture models, such as spheroids, scaffolds, organoids, and organs-on-a-chip, that are used in virus research, including those used to understand the new severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).
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