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10.3390/v13061037 http://scihub22266oqcxt.onion/10.3390/v13061037 34072720!8226613!34072720     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (6): ä Nephropedia Template TP {{tp|p=34072720|t=2021. Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus Infections |pdf=|usr=}}{{34072720}} gab.com Text Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus Infections JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34072720 #FOAvip Identification of therapeutics against emerging and re-emerging viruses remains a continued priority that is only reinforced by the recent SARS-CoV-2 pandemic. Advances in monoclonal antibody (mAb) isolation, characterization, and production make it a viable option for rapid treatment development. While mAbs are traditionally screened and selected based on potency of neutralization in vitro, it is clear that additional factors contribute to the in vivo efficacy of a mAb beyond viral neutralization. These factors include interactions with Fc receptors (FcRs) and complement that can enhance neutralization, clearance of infected cells, opsonization of virions, and modulation of the innate and adaptive immune response. In this review, we discuss recent studies, primarily using mouse models, that identified a role for Fc-FcgammaR interactions for optimal antibody-based protection against emerging and re-emerging virus infections. Twit Text FOAVip Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus Infections ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34072720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34072720 #FOAvip English Wikipedia <ref>{{Cite pmid|34072720}}</ref> Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus Infections #MMPMID34072720 Keeler SP; Fox JM Viruses 2021[May]; 13 (6): ä PMID34072720show ga Identification of therapeutics against emerging and re-emerging viruses remains a continued priority that is only reinforced by the recent SARS-CoV-2 pandemic. Advances in monoclonal antibody (mAb) isolation, characterization, and production make it a viable option for rapid treatment development. While mAbs are traditionally screened and selected based on potency of neutralization in vitro, it is clear that additional factors contribute to the in vivo efficacy of a mAb beyond viral neutralization. These factors include interactions with Fc receptors (FcRs) and complement that can enhance neutralization, clearance of infected cells, opsonization of virions, and modulation of the innate and adaptive immune response. In this review, we discuss recent studies, primarily using mouse models, that identified a role for Fc-FcgammaR interactions for optimal antibody-based protection against emerging and re-emerging virus infections. |Animals[MESH] |Antibodies, Monoclonal/immunology/therapeutic use[MESH] |Antibodies, Neutralizing/immunology/therapeutic use[MESH] |Antibody-Dependent Cell Cytotoxicity[MESH] |Communicable Diseases, Emerging/*immunology/therapy/virology[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Immunoglobulin Fc Fragments/*immunology[MESH] |Phagocytosis[MESH] |Receptors, IgG/*immunology[MESH] |Virus Diseases/*immunology/therapy/virology[MESH]Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Pro(epmc).pdf DeepDyve Pubget Overpricing