Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3390/ijms22115817 http://scihub22266oqcxt.onion/10.3390/ijms22115817 34072295!8199346!34072295     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (11): ä Nephropedia Template TP {{tp|p=34072295|t=2021. Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases |pdf=|usr=}}{{34072295}} gab.com Text Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34072295 #FOAvip Trypsin-like proteases (TLPs) belong to a family of serine enzymes with primary substrate specificities for the basic residues, lysine and arginine, in the P1 position. Whilst initially perceived as soluble enzymes that are extracellularly secreted, a number of novel TLPs that are anchored in the cell membrane have since been discovered. Muco-obstructive lung diseases (MucOLDs) are characterised by the accumulation of hyper-concentrated mucus in the small airways, leading to persistent inflammation, infection and dysregulated protease activity. Although neutrophilic serine proteases, particularly neutrophil elastase, have been implicated in the propagation of inflammation and local tissue destruction, it is likely that the serine TLPs also contribute to various disease-relevant processes given the roles that a number of these enzymes play in the activation of both the epithelial sodium channel (ENaC) and protease-activated receptor 2 (PAR2). More recently, significant attention has focused on the activation of viruses such as SARS-CoV-2 by host TLPs. The purpose of this review was to highlight key TLPs linked to the activation of ENaC and PAR2 and their association with airway dehydration and inflammatory signalling pathways, respectively. The role of TLPs in viral infectivity will also be discussed in the context of the inhibition of TLP activities and the potential of these proteases as therapeutic targets. Twit Text FOAVip Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34072295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34072295 #FOAvip English Wikipedia <ref>{{Cite pmid|34072295}}</ref> Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases #MMPMID34072295 Carroll EL; Bailo M; Reihill JA; Crilly A; Lockhart JC; Litherland GJ; Lundy FT; McGarvey LP; Hollywood MA; Martin SL Int J Mol Sci 2021[May]; 22 (11): ä PMID34072295show ga Trypsin-like proteases (TLPs) belong to a family of serine enzymes with primary substrate specificities for the basic residues, lysine and arginine, in the P1 position. Whilst initially perceived as soluble enzymes that are extracellularly secreted, a number of novel TLPs that are anchored in the cell membrane have since been discovered. Muco-obstructive lung diseases (MucOLDs) are characterised by the accumulation of hyper-concentrated mucus in the small airways, leading to persistent inflammation, infection and dysregulated protease activity. Although neutrophilic serine proteases, particularly neutrophil elastase, have been implicated in the propagation of inflammation and local tissue destruction, it is likely that the serine TLPs also contribute to various disease-relevant processes given the roles that a number of these enzymes play in the activation of both the epithelial sodium channel (ENaC) and protease-activated receptor 2 (PAR2). More recently, significant attention has focused on the activation of viruses such as SARS-CoV-2 by host TLPs. The purpose of this review was to highlight key TLPs linked to the activation of ENaC and PAR2 and their association with airway dehydration and inflammatory signalling pathways, respectively. The role of TLPs in viral infectivity will also be discussed in the context of the inhibition of TLP activities and the potential of these proteases as therapeutic targets. |Animals[MESH] |COVID-19/*enzymology/pathology[MESH] |Epithelial Sodium Channels/metabolism[MESH] |Humans[MESH] |Lung Diseases, Obstructive/*enzymology/pathology[MESH] |Receptor, PAR-2/metabolism[MESH] |SARS-CoV-2/*metabolism[MESH]Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Disease(epmc).pdf DeepDyve Pubget Overpricing