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10.3390/v13061018 http://scihub22266oqcxt.onion/10.3390/v13061018 34071557!8228164!34071557     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34071557&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Viruses 2021 ; 13 (6): ? Nephropedia Template TP {{tp|p=34071557|t=2021. COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation |pdf=|usr=}}{{34071557}} gab.com Text COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34071557 #FOAvip Patients with underlying cardiovascular conditions are particularly vulnerable to severe COVID-19. In this project, we aimed to characterize similarities in dysregulated immune pathways between COVID-19 patients and patients with cardiomyopathy, venous thromboembolism (VTE), or coronary artery disease (CAD). We hypothesized that these similarly dysregulated pathways may be critical to how cardiovascular diseases (CVDs) exacerbate COVID-19. To evaluate immune dysregulation in different diseases, we used four separate datasets, including RNA-sequencing data from human left ventricular cardiac muscle samples of patients with dilated or ischemic cardiomyopathy and healthy controls; RNA-sequencing data of whole blood samples from patients with single or recurrent event VTE and healthy controls; RNA-sequencing data of human peripheral blood mononuclear cells (PBMCs) from patients with and without obstructive CAD; and RNA-sequencing data of platelets from COVID-19 subjects and healthy controls. We found similar immune dysregulation profiles between patients with CVDs and COVID-19 patients. Interestingly, cardiomyopathy patients display the most similar immune landscape to COVID-19 patients. Additionally, COVID-19 patients experience greater upregulation of cytokine- and inflammasome-related genes than patients with CVDs. In all, patients with CVDs have a significant overlap of cytokine- and inflammasome-related gene expression profiles with that of COVID-19 patients, possibly explaining their greater vulnerability to severe COVID-19. Twit Text FOAVip COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34071557 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34071557 #FOAvip English Wikipedia <ref>{{Cite pmid|34071557}}</ref> COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation #MMPMID34071557 Lee AC; Castaneda G; Li WT; Chen C; Shende N; Chakladar J; Taub PR; Chang EY; Ongkeko WM Viruses 2021[May]; 13 (6): ? PMID34071557show ga Patients with underlying cardiovascular conditions are particularly vulnerable to severe COVID-19. In this project, we aimed to characterize similarities in dysregulated immune pathways between COVID-19 patients and patients with cardiomyopathy, venous thromboembolism (VTE), or coronary artery disease (CAD). We hypothesized that these similarly dysregulated pathways may be critical to how cardiovascular diseases (CVDs) exacerbate COVID-19. To evaluate immune dysregulation in different diseases, we used four separate datasets, including RNA-sequencing data from human left ventricular cardiac muscle samples of patients with dilated or ischemic cardiomyopathy and healthy controls; RNA-sequencing data of whole blood samples from patients with single or recurrent event VTE and healthy controls; RNA-sequencing data of human peripheral blood mononuclear cells (PBMCs) from patients with and without obstructive CAD; and RNA-sequencing data of platelets from COVID-19 subjects and healthy controls. We found similar immune dysregulation profiles between patients with CVDs and COVID-19 patients. Interestingly, cardiomyopathy patients display the most similar immune landscape to COVID-19 patients. Additionally, COVID-19 patients experience greater upregulation of cytokine- and inflammasome-related genes than patients with CVDs. In all, patients with CVDs have a significant overlap of cytokine- and inflammasome-related gene expression profiles with that of COVID-19 patients, possibly explaining their greater vulnerability to severe COVID-19. |COVID-19/complications/genetics/*immunology/*physiopathology[MESH] |Cardiomyopathies/complications/genetics/*immunology[MESH] |Coronary Artery Disease/complications/genetics/*immunology[MESH] |Cytokines/genetics[MESH] |Datasets as Topic[MESH] |Humans[MESH] |Immunocompromised Host/genetics[MESH] |Inflammasomes/genetics[MESH] |Lymphocyte Count[MESH] |Patient Acuity[MESH] |RNA-Seq[MESH]COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Asso(epmc).pdf DeepDyve Pubget Overpricing