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10.3390/ijms22115762

http://scihub22266oqcxt.onion/10.3390/ijms22115762
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34071206!8197795!34071206
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suck abstract from ncbi


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pmid34071206      Int+J+Mol+Sci 2021 ; 22 (11): ä
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  • Protease Inhibition-An Established Strategy to Combat Infectious Diseases #MMPMID34071206
  • Sojka D; Snebergerova P; Robbertse L
  • Int J Mol Sci 2021[May]; 22 (11): ä PMID34071206show ga
  • Therapeutic agents with novel mechanisms of action are urgently needed to counter the emergence of drug-resistant infections. Several decades of research into proteases of disease agents have revealed enzymes well suited for target-based drug development. Among them are the three recently validated proteolytic targets: proteasomes of the malarial parasite Plasmodium falciparum, aspartyl proteases of P. falciparum (plasmepsins) and the Sars-CoV-2 viral proteases. Despite some unfulfilled expectations over previous decades, the three reviewed targets clearly demonstrate that selective protease inhibitors provide effective therapeutic solutions for the two most impacting infectious diseases nowadays-malaria and COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aspartic Acid Endopeptidases/metabolism[MESH]
  • |COVID-19/enzymology/metabolism[MESH]
  • |Drug Development/*methods[MESH]
  • |Humans[MESH]
  • |Malaria/*drug therapy/enzymology/metabolism[MESH]
  • |Plasmodium falciparum/*drug effects/pathogenicity[MESH]
  • |Protease Inhibitors/*pharmacology[MESH]
  • |Proteasome Endopeptidase Complex/*drug effects[MESH]


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