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10.3390/v13060966 http://scihub22266oqcxt.onion/10.3390/v13060966 34071034!8224554!34071034     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34071034&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Viruses 2021 ; 13 (6): ? Nephropedia Template TP {{tp|p=34071034|t=2021. GABA(A)-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice |pdf=|usr=}}{{34071034}} gab.com Text GABA(A)-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34071034 #FOAvip There is an urgent need for new approaches to limit the severity of coronavirus infections. Many cells of the immune system express receptors for the neurotransmitter gamma-aminobutyric acid (GABA), and GABA-receptor (GABA-R) agonists have anti-inflammatory effects. Lung epithelial cells also express GABA-Rs, and GABA-R modulators have been shown to limit acute lung injuries. There is currently, however, no information on whether GABA-R agonists might impact the course of a viral infection. Here, we assessed whether clinically applicable GABA-R agonists could be repurposed for the treatment of a lethal coronavirus (murine hepatitis virus 1, MHV-1) infection in mice. We found that oral GABA administration before, or after the appearance of symptoms, very effectively limited MHV-1-induced pneumonitis, severe illness, and death. GABA treatment also reduced viral load in the lungs, suggesting that GABA-Rs may provide a new druggable target to limit coronavirus replication. Treatment with the GABA(A)-R-specific agonist homotaurine, but not the GABA(B)-R-specific agonist baclofen, significantly reduced the severity of pneumonitis and death rates in MHV-1-infected mice, indicating that the therapeutic effects were mediated primarily through GABA(A)-Rs. Since GABA and homotaurine are safe for human consumption, they are promising candidates to help treat coronavirus infections. Twit Text FOAVip GABA(A)-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34071034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34071034 #FOAvip English Wikipedia <ref>{{Cite pmid|34071034}}</ref> GABA(A)-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice #MMPMID34071034 Tian J; Middleton B; Kaufman DL Viruses 2021[May]; 13 (6): ? PMID34071034show ga There is an urgent need for new approaches to limit the severity of coronavirus infections. Many cells of the immune system express receptors for the neurotransmitter gamma-aminobutyric acid (GABA), and GABA-receptor (GABA-R) agonists have anti-inflammatory effects. Lung epithelial cells also express GABA-Rs, and GABA-R modulators have been shown to limit acute lung injuries. There is currently, however, no information on whether GABA-R agonists might impact the course of a viral infection. Here, we assessed whether clinically applicable GABA-R agonists could be repurposed for the treatment of a lethal coronavirus (murine hepatitis virus 1, MHV-1) infection in mice. We found that oral GABA administration before, or after the appearance of symptoms, very effectively limited MHV-1-induced pneumonitis, severe illness, and death. GABA treatment also reduced viral load in the lungs, suggesting that GABA-Rs may provide a new druggable target to limit coronavirus replication. Treatment with the GABA(A)-R-specific agonist homotaurine, but not the GABA(B)-R-specific agonist baclofen, significantly reduced the severity of pneumonitis and death rates in MHV-1-infected mice, indicating that the therapeutic effects were mediated primarily through GABA(A)-Rs. Since GABA and homotaurine are safe for human consumption, they are promising candidates to help treat coronavirus infections. |Animals[MESH] |Coronavirus Infections/*drug therapy/mortality/virology[MESH] |GABA-A Receptor Agonists/*therapeutic use[MESH] |Lung/drug effects/pathology/virology[MESH] |Mice[MESH] |Murine hepatitis virus/*drug effects/pathogenicity[MESH] |Pneumonia/*drug therapy/mortality/virology[MESH] |Severity of Illness Index[MESH] |Treatment Outcome[MESH] |Viral Load/drug effects[MESH] |Weight Loss/drug effects[MESH]GABA(A)-Receptor Agonists Limit Pneumonitis and Death in Murine Coron(epmc).pdf DeepDyve Pubget Overpricing