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10.3390/cells10061291 http://scihub22266oqcxt.onion/10.3390/cells10061291 34070971!8224694!34070971     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34070971&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cells 2021 ; 10 (6): ? Nephropedia Template TP {{tp|p=34070971|t=2021. Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries |pdf=|usr=}}{{34070971}} gab.com Text Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=34070971 #FOAvip The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans. Twit Text FOAVip Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=34070971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34070971 #FOAvip English Wikipedia <ref>{{Cite pmid|34070971}}</ref> Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries #MMPMID34070971 Lado S; Elbers JP; Plasil M; Loney T; Weidinger P; Camp JV; Kolodziejek J; Futas J; Kannan DA; Orozco-terWengel P; Horin P; Nowotny N; Burger PA Cells 2021[May]; 10 (6): ? PMID34070971show ga The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans. |Adaptive Immunity/*genetics[MESH] |Animals[MESH] |Antibodies, Viral[MESH] |Bronchi/cytology/physiology[MESH] |COVID-19/genetics/immunology/virology[MESH] |Camelus/genetics/immunology/*virology[MESH] |Cilia/physiology[MESH] |Communicable Diseases, Emerging/genetics/*immunology/transmission/virology[MESH] |Coronavirus Infections/genetics/*immunology/transmission/virology[MESH] |Disease Reservoirs/virology[MESH] |Female[MESH] |Genetic Predisposition to Disease[MESH] |Host Microbial Interactions/genetics/immunology[MESH] |Humans[MESH] |Immunity, Innate/*genetics[MESH] |Male[MESH] |Middle East Respiratory Syndrome Coronavirus/immunology/isolation & purification/pathogenicity[MESH] |Respiratory Mucosa/cytology/physiology[MESH] |SARS-CoV-2/immunology/pathogenicity[MESH] |United Arab Emirates[MESH] |Virus Replication/genetics/immunology[MESH]Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in(epmc).pdf DeepDyve Pubget Overpricing