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10.3390/v13060980 http://scihub22266oqcxt.onion/10.3390/v13060980 34070524!8227008!34070524     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34070524&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (6): ä Nephropedia Template TP {{tp|p=34070524|t=2021. Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 |pdf=|usr=}}{{34070524}} gab.com Text Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34070524 #FOAvip SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. To this end, we evaluated a new class of organometallic complexes as potential antivirals. Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool complexes, Cp*Rh(1,3-dicyclohexylimidazol-2-ylidene)Cl(2) (complex 2) and Cp*Rh(dipivaloylmethanato)Cl (complex 4), have direct virucidal activity against SARS-CoV-2. Subsequent in vitro testing suggests that complex 4 is the more stable and effective complex and demonstrates that both 2 and 4 have low toxicity in Vero E6 and Calu-3 cells. The results presented here highlight the potential application of organometallic complexes as antivirals and support further investigation into their activity. Twit Text FOAVip Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34070524 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34070524 #FOAvip English Wikipedia <ref>{{Cite pmid|34070524}}</ref> Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 #MMPMID34070524 Chuong C; DuChane CM; Webb EM; Rai P; Marano JM; Bernier CM; Merola JS; Weger-Lucarelli J Viruses 2021[May]; 13 (6): ä PMID34070524show ga SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. To this end, we evaluated a new class of organometallic complexes as potential antivirals. Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool complexes, Cp*Rh(1,3-dicyclohexylimidazol-2-ylidene)Cl(2) (complex 2) and Cp*Rh(dipivaloylmethanato)Cl (complex 4), have direct virucidal activity against SARS-CoV-2. Subsequent in vitro testing suggests that complex 4 is the more stable and effective complex and demonstrates that both 2 and 4 have low toxicity in Vero E6 and Calu-3 cells. The results presented here highlight the potential application of organometallic complexes as antivirals and support further investigation into their activity. |Animals[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |COVID-19/virology[MESH] |Cell Line[MESH] |Cell Survival/drug effects[MESH] |Chlorocebus aethiops[MESH] |Dose-Response Relationship, Drug[MESH] |Humans[MESH] |Molecular Structure[MESH] |Organometallic Compounds/chemistry/*pharmacology[MESH] |SARS-CoV-2/*drug effects/physiology[MESH] |Vero Cells[MESH]Noble Metal Organometallic Complexes Display Antiviral Activity agains(epmc).pdf DeepDyve Pubget Overpricing