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10.3390/pathogens10050623

http://scihub22266oqcxt.onion/10.3390/pathogens10050623
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34069460!8159111!34069460
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suck abstract from ncbi


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pmid34069460      Pathogens 2021 ; 10 (5): ä
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  • Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate #MMPMID34069460
  • Soltane R; Chrouda A; Mostafa A; Al-Karmalawy AA; Chouaib K; Dhahri A; Pashameah RA; Alasiri A; Kutkat O; Shehata M; Jannet HB; Gharbi J; Ali MA
  • Pathogens 2021[May]; 10 (5): ä PMID34069460show ga
  • In late December 2019, a novel coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), escaped the animal-human interface and emerged as an ongoing global pandemic with severe flu-like illness, commonly known as coronavirus disease 2019 (COVID-19). In this study, a molecular docking study was carried out for seventeen (17) structural analogues prepared from natural maslinic and oleanolic acids, screened against SARS-CoV-2 main protease. Furthermore, we experimentally validated the virtual data by measuring the half-maximal cytotoxic and inhibitory concentrations of each compound. Interestingly, the chlorinated isoxazole linked maslinic acid (compound 17) showed promising antiviral activity at micromolar non-toxic concentrations. Thoughtfully, we showed that compound 17 mainly impairs the viral replication of SARS-CoV-2. Furthermore, a very promising SAR study for the examined compounds was concluded, which could be used by medicinal chemists in the near future for the design and synthesis of potential anti-SARS-CoV-2 candidates. Our results could be very promising for performing further additional in vitro and in vivo studies on the tested compound (17) before further licensing for COVID-19 treatment.
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