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10.3390/v13050874

http://scihub22266oqcxt.onion/10.3390/v13050874
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34068703!8151912!34068703
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suck abstract from ncbi


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pmid34068703      Viruses 2021 ; 13 (5): ä
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  • Virological Correlates of IgM-IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens #MMPMID34068703
  • Barreiro P; Candel FJ; Sanz JC; San Roman J; Del Mar Carretero M; Perez-Abeledo M; Ramos B; Vinuela-Prieto JM; Canora J; Martinez-Peromingo FJ; Zapatero A
  • Viruses 2021[May]; 13 (5): ä PMID34068703show ga
  • The virological meaning of the different patterns of serology in COVID-19 has been little examined in clinical settings. Asymptomatic subjects with IgM-spike (S) and IgG-nucleocapsid (N) determinations by chemiluminescence were studied for SARS-CoV-2 shedding in respiratory secretions by transcription-mediated amplification (TMA). In subjects showing IgM-S positive and IgG-N negative, IgG-S was determined by lateral flow assay. A total of 712 individuals were tested: 30.0% presented IgM-S(+)/IgG-N(-), 25.8% had IgM-S(+)/IgG-N(+) and 44.2% had IgM-S(-)/IgG-N(+); the proportion with TMA(+) were comparable in these three groups: 12.1, 8.7 and 10.5%, respectively. In individuals with IgM-S(+)/IgG-N(-), IgG-S(+) was detected in 66.5%. The frequency of IgM-S(+)/IgG-S(-) in the total population was 10.0%, of whom 24.1% had TMA(+); the chances for TMA(+) in subjects with an IgM-S(+) alone pattern were 2.4%. Targeting of the same SARS-CoV-2 antigen seems to be better for the characterization of IgM/IgG patterns of response. IgM-S(+) alone reactivity is rare, and a small proportion is associated with viral shedding.
  • |Antibodies, Viral/*blood[MESH]
  • |Antigens, Viral/immunology[MESH]
  • |COVID-19 Serological Testing[MESH]
  • |COVID-19/diagnosis/*immunology[MESH]
  • |Coronavirus Nucleocapsid Proteins/*immunology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood[MESH]
  • |Immunoglobulin M/blood[MESH]
  • |Nasopharynx/virology[MESH]
  • |Phosphoproteins/immunology[MESH]
  • |Sensitivity and Specificity[MESH]


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