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10.3390/genes12050734 http://scihub22266oqcxt.onion/10.3390/genes12050734 34068220!8153134!34068220     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+(Basel) 2021 ; 12 (5): ä Nephropedia Template TP {{tp|p=34068220|t=2021. The Molecular Basis of Calcium and Phosphorus Inherited Metabolic Disorders |pdf=|usr=}}{{34068220}} gab.com Text The Molecular Basis of Calcium and Phosphorus Inherited Metabolic Disorders JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34068220 #FOAvip Calcium (Ca) and Phosphorus (P) hold a leading part in many skeletal and extra-skeletal biological processes. Their tight normal range in serum mirrors their critical role in human well-being. The signalling "voyage" starts at Calcium Sensing Receptor (CaSR) localized on the surface of the parathyroid glands, which captures the "oscillations" of extracellular ionized Ca and transfers the signal downstream. Parathyroid hormone (PTH), Vitamin D, Fibroblast Growth Factor (FGF23) and other receptors or ion-transporters, work synergistically and establish a highly regulated signalling circuit between the bone, kidneys, and intestine to ensure the maintenance of Ca and P homeostasis. Any deviation from this well-orchestrated scheme may result in mild or severe pathologies expressed by biochemical and/or clinical features. Inherited disorders of Ca and P metabolism are rare. However, delayed diagnosis or misdiagnosis may cost patient's quality of life or even life expectancy. Unravelling the thread of the molecular pathways involving Ca and P signaling, we can better understand the link between genetic alterations and biochemical and/or clinical phenotypes and help in diagnosis and early therapeutic intervention. Twit Text FOAVip The Molecular Basis of Calcium and Phosphorus Inherited Metabolic Disorders ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34068220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34068220 #FOAvip English Wikipedia <ref>{{Cite pmid|34068220}}</ref> The Molecular Basis of Calcium and Phosphorus Inherited Metabolic Disorders #MMPMID34068220 Papadopoulou A; Bountouvi E; Karachaliou FE Genes (Basel) 2021[May]; 12 (5): ä PMID34068220show ga Calcium (Ca) and Phosphorus (P) hold a leading part in many skeletal and extra-skeletal biological processes. Their tight normal range in serum mirrors their critical role in human well-being. The signalling "voyage" starts at Calcium Sensing Receptor (CaSR) localized on the surface of the parathyroid glands, which captures the "oscillations" of extracellular ionized Ca and transfers the signal downstream. Parathyroid hormone (PTH), Vitamin D, Fibroblast Growth Factor (FGF23) and other receptors or ion-transporters, work synergistically and establish a highly regulated signalling circuit between the bone, kidneys, and intestine to ensure the maintenance of Ca and P homeostasis. Any deviation from this well-orchestrated scheme may result in mild or severe pathologies expressed by biochemical and/or clinical features. Inherited disorders of Ca and P metabolism are rare. However, delayed diagnosis or misdiagnosis may cost patient's quality of life or even life expectancy. Unravelling the thread of the molecular pathways involving Ca and P signaling, we can better understand the link between genetic alterations and biochemical and/or clinical phenotypes and help in diagnosis and early therapeutic intervention. |Animals[MESH] |Calcium Metabolism Disorders/*genetics/metabolism/pathology[MESH] |Calcium/metabolism[MESH] |Fibroblast Growth Factor-23[MESH] |Humans[MESH] |Mutation[MESH] |Phosphorus Metabolism Disorders/*genetics/metabolism/pathology[MESH]The Molecular Basis of Calcium and Phosphorus Inherited Metabolic Diso(epmc).pdf DeepDyve Pubget Overpricing