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10.3390/cells10051130 http://scihub22266oqcxt.onion/10.3390/cells10051130 34067054!8150892!34067054     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2021 ; 10 (5): ä Nephropedia Template TP {{tp|p=34067054|t=2021. The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection |pdf=|usr=}}{{34067054}} gab.com Text The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=34067054 #FOAvip The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing TPC activity. The goal of the present review is to illustrate the rationale that links TPC channels to the mechanism of coronavirus infection, and how their inhibition by Nar could be an efficient pharmacological strategy to fight the current pandemic plague COVID-19. Twit Text FOAVip The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=34067054 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34067054 #FOAvip English Wikipedia <ref>{{Cite pmid|34067054}}</ref> The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection #MMPMID34067054 D'Amore A; Gradogna A; Palombi F; Minicozzi V; Ceccarelli M; Carpaneto A; Filippini A Cells 2021[May]; 10 (5): ä PMID34067054show ga The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing TPC activity. The goal of the present review is to illustrate the rationale that links TPC channels to the mechanism of coronavirus infection, and how their inhibition by Nar could be an efficient pharmacological strategy to fight the current pandemic plague COVID-19. |*COVID-19 Drug Treatment[MESH] |Antineoplastic Agents/pharmacology/therapeutic use[MESH] |Antiviral Agents/pharmacology/therapeutic use[MESH] |Arabidopsis/metabolism[MESH] |COVID-19/epidemiology/pathology/virology[MESH] |Calcium Channel Blockers/*pharmacology/therapeutic use[MESH] |Calcium Channels/*metabolism[MESH] |Drug Evaluation, Preclinical[MESH] |Endosomes/drug effects/metabolism/virology[MESH] |Flavanones/*pharmacology/therapeutic use[MESH] |Humans[MESH] |Lysosomes/drug effects/metabolism/virology[MESH] |Neoplasms/blood supply/*drug therapy/pathology[MESH] |Neovascularization, Pathologic/drug therapy/pathology[MESH] |Pandemics/prevention & control[MESH] |SARS-CoV-2/pathogenicity[MESH] |Vacuoles/metabolism[MESH]The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibito(epmc).pdf DeepDyve Pubget Overpricing