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10.3390/v13050832 http://scihub22266oqcxt.onion/10.3390/v13050832 34064525!8147968!34064525     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (5): ä Nephropedia Template TP {{tp|p=34064525|t=2021. Identification of the SHREK Family of Proteins as Broad-Spectrum Host Antiviral Factors |pdf=|usr=}}{{34064525}} gab.com Text Identification of the SHREK Family of Proteins as Broad-Spectrum Host Antiviral Factors JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34064525 #FOAvip Mucins and mucin-like molecules are highly glycosylated, high-molecular-weight cell surface proteins that possess a semi-rigid and highly extended extracellular domain. P-selectin glycoprotein ligand-1 (PSGL-1), a mucin-like glycoprotein, has recently been found to restrict HIV-1 infectivity through virion incorporation that sterically hinders virus particle attachment to target cells. Here, we report the identification of a family of antiviral cellular proteins, named the Surface-Hinged, Rigidly-Extended Killer (SHREK) family of virion inactivators (PSGL-1, CD43, TIM-1, CD34, PODXL1, PODXL2, CD164, MUC1, MUC4, and TMEM123) that share similar structural characteristics with PSGL-1. We demonstrate that SHREK proteins block HIV-1 infectivity by inhibiting virus particle attachment to target cells. In addition, we demonstrate that SHREK proteins are broad-spectrum host antiviral factors that block the infection of diverse viruses such as influenza A. Furthermore, we demonstrate that a subset of SHREKs also blocks the infectivity of a hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) pseudovirus. These results suggest that SHREK proteins may be a part of host innate immunity against enveloped viruses. Twit Text FOAVip Identification of the SHREK Family of Proteins as Broad-Spectrum Host Antiviral Factors ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34064525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34064525 #FOAvip English Wikipedia <ref>{{Cite pmid|34064525}}</ref> Identification of the SHREK Family of Proteins as Broad-Spectrum Host Antiviral Factors #MMPMID34064525 Dabbagh D; He S; Hetrick B; Chilin L; Andalibi A; Wu Y Viruses 2021[May]; 13 (5): ä PMID34064525show ga Mucins and mucin-like molecules are highly glycosylated, high-molecular-weight cell surface proteins that possess a semi-rigid and highly extended extracellular domain. P-selectin glycoprotein ligand-1 (PSGL-1), a mucin-like glycoprotein, has recently been found to restrict HIV-1 infectivity through virion incorporation that sterically hinders virus particle attachment to target cells. Here, we report the identification of a family of antiviral cellular proteins, named the Surface-Hinged, Rigidly-Extended Killer (SHREK) family of virion inactivators (PSGL-1, CD43, TIM-1, CD34, PODXL1, PODXL2, CD164, MUC1, MUC4, and TMEM123) that share similar structural characteristics with PSGL-1. We demonstrate that SHREK proteins block HIV-1 infectivity by inhibiting virus particle attachment to target cells. In addition, we demonstrate that SHREK proteins are broad-spectrum host antiviral factors that block the infection of diverse viruses such as influenza A. Furthermore, we demonstrate that a subset of SHREKs also blocks the infectivity of a hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) pseudovirus. These results suggest that SHREK proteins may be a part of host innate immunity against enveloped viruses. |*Virus Attachment[MESH] |Animals[MESH] |COVID-19/*immunology/virology[MESH] |Dogs[MESH] |HEK293 Cells[MESH] |HIV Infections/*immunology[MESH] |HIV-1/immunology[MESH] |HeLa Cells[MESH] |Host Microbial Interactions[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Madin Darby Canine Kidney Cells[MESH] |Membrane Glycoproteins/*metabolism[MESH] |Mucins/pharmacology[MESH]Identification of the SHREK Family of Proteins as Broad-Spectrum Host (epmc).pdf DeepDyve Pubget Overpricing