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10.3390/cells10051103 http://scihub22266oqcxt.onion/10.3390/cells10051103 34064487!8147922!34064487     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34064487&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cells 2021 ; 10 (5): ? Nephropedia Template TP {{tp|p=34064487|t=2021. Hepatic Failure in COVID-19: Is Iron Overload the Dangerous Trigger?|pdf=|usr=}}{{34064487}} gab.com Text Hepatic Failure in COVID-19: Is Iron Overload the Dangerous Trigger JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=34064487 #FOAvip Liver injury in COVID-19 patients has progressively emerged, even in those without a history of liver disease, yet the mechanism of liver pathogenicity is still controversial. COVID-19 is frequently associated with increased serum ferritin levels, and hyperferritinemia was shown to correlate with illness severity. The liver is the major site for iron storage, and conditions of iron overload have been established to have a pathogenic role in development of liver diseases. We presented here six patients who developed severe COVID-19, with biochemical evidence of liver failure. Three cases were survived patients, who underwent liver biopsy; the other three were deceased patients, who were autopsied. None of the patients suffered underlying liver pathologies. Histopathological and ultrastructural analyses were performed. The most striking finding we demonstrated in all patients was iron accumulation into hepatocytes, associated with degenerative changes. Abundant ferritin particles were found enclosed in siderosomes, and large aggregates of hemosiderin were found, often in close contact with damaged mitochondria. Iron-caused oxidative stress may be responsible for mitochondria metabolic dysfunction. In agreement with this, association between mitochondria and lipid droplets was also found. Overall, our data suggest that hepatic iron overload could be the pathogenic trigger of liver injury associated to COVID-19. Twit Text FOAVip Hepatic Failure in COVID-19: Is Iron Overload the Dangerous Trigger ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=34064487 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34064487 #FOAvip English Wikipedia <ref>{{Cite pmid|34064487}}</ref> Hepatic Failure in COVID-19: Is Iron Overload the Dangerous Trigger? #MMPMID34064487 Del Nonno F; Nardacci R; Colombo D; Visco-Comandini U; Cicalini S; Antinori A; Marchioni L; D'Offizi G; Piacentini M; Falasca L Cells 2021[May]; 10 (5): ? PMID34064487show ga Liver injury in COVID-19 patients has progressively emerged, even in those without a history of liver disease, yet the mechanism of liver pathogenicity is still controversial. COVID-19 is frequently associated with increased serum ferritin levels, and hyperferritinemia was shown to correlate with illness severity. The liver is the major site for iron storage, and conditions of iron overload have been established to have a pathogenic role in development of liver diseases. We presented here six patients who developed severe COVID-19, with biochemical evidence of liver failure. Three cases were survived patients, who underwent liver biopsy; the other three were deceased patients, who were autopsied. None of the patients suffered underlying liver pathologies. Histopathological and ultrastructural analyses were performed. The most striking finding we demonstrated in all patients was iron accumulation into hepatocytes, associated with degenerative changes. Abundant ferritin particles were found enclosed in siderosomes, and large aggregates of hemosiderin were found, often in close contact with damaged mitochondria. Iron-caused oxidative stress may be responsible for mitochondria metabolic dysfunction. In agreement with this, association between mitochondria and lipid droplets was also found. Overall, our data suggest that hepatic iron overload could be the pathogenic trigger of liver injury associated to COVID-19. |*Severity of Illness Index[MESH] |Adult[MESH] |Aged[MESH] |Antiviral Agents[MESH] |Biopsy[MESH] |COVID-19/complications/*diagnosis/mortality/therapy[MESH] |Female[MESH] |Ferritins/analysis[MESH] |Hepatocytes/cytology/pathology[MESH] |Humans[MESH] |Iron Overload/*etiology/mortality/pathology/therapy[MESH] |Iron/analysis/metabolism[MESH] |Liver Failure/*etiology/mortality/pathology/therapy[MESH] |Liver Function Tests[MESH] |Liver/cytology/metabolism/*pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Mitochondria/pathology[MESH] |Positive-Pressure Respiration[MESH]Hepatic Failure in COVID-19: Is Iron Overload the Dangerous Trigger?(epmc).pdf DeepDyve Pubget Overpricing