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10.3390/biology10060454 http://scihub22266oqcxt.onion/10.3390/biology10060454 34064163!8224284!34064163     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34064163&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biology+(Basel) 2021 ; 10 (6): ä Nephropedia Template TP {{tp|p=34064163|t=2021. Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility |pdf=|usr=}}{{34064163}} gab.com Text Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility JO: Biology (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34064163 #FOAvip The latest coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia leading to the pandemic, contains 29 proteins. Among them, nucleocapsid protein (N(CoV2)) is one of the abundant proteins and shows multiple functions including packaging the RNA genome during the infection cycle. It has also emerged as a potential drug target. In this review, the current status of the research of N(CoV2) is described in terms of molecular structure and dynamics. N(CoV2) consists of two domains, i.e., the N-terminal domain (NTD) and the C-terminal domain (CTD) with a disordered region between them. Recent simulation studies have identified several potential drugs that can bind to NTD or CTD with high affinity. Moreover, it was shown that the degree of flexibility in the disordered region has a large effect on drug binding rate, suggesting the importance of molecular flexibility for the N(CoV2) function. Molecular flexibility has also been shown to be integral to the formation of droplets, where N(CoV2), RNA and/or other viral proteins gather through liquid-liquid phase separation and considered important for viral replication. Finally, as one of the future research directions, a strategy for obtaining the structural and dynamical information on the proteins contained in droplets is presented. Twit Text FOAVip Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility ????Biology (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34064163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34064163 #FOAvip English Wikipedia <ref>{{Cite pmid|34064163}}</ref> Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility #MMPMID34064163 Matsuo T Biology (Basel) 2021[May]; 10 (6): ä PMID34064163show ga The latest coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia leading to the pandemic, contains 29 proteins. Among them, nucleocapsid protein (N(CoV2)) is one of the abundant proteins and shows multiple functions including packaging the RNA genome during the infection cycle. It has also emerged as a potential drug target. In this review, the current status of the research of N(CoV2) is described in terms of molecular structure and dynamics. N(CoV2) consists of two domains, i.e., the N-terminal domain (NTD) and the C-terminal domain (CTD) with a disordered region between them. Recent simulation studies have identified several potential drugs that can bind to NTD or CTD with high affinity. Moreover, it was shown that the degree of flexibility in the disordered region has a large effect on drug binding rate, suggesting the importance of molecular flexibility for the N(CoV2) function. Molecular flexibility has also been shown to be integral to the formation of droplets, where N(CoV2), RNA and/or other viral proteins gather through liquid-liquid phase separation and considered important for viral replication. Finally, as one of the future research directions, a strategy for obtaining the structural and dynamical information on the proteins contained in droplets is presented. äViewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibil(epmc).pdf DeepDyve Pubget Overpricing