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10.3390/bios11050141 http://scihub22266oqcxt.onion/10.3390/bios11050141 34062874!8147281!34062874     free     free     free       Biosensors+(Basel) 2021 ; 11 (5): ä Nephropedia Template TP {{tp|p=34062874|t=2021. Point-of-Care PCR Assays for COVID-19 Detection |pdf=|usr=}}{{34062874}} gab.com Text Point-of-Care PCR Assays for COVID-19 Detection JO: Biosensors (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34062874 #FOAvip Molecular diagnostics has been the front runner in the world's response to the COVID-19 pandemic. Particularly, reverse transcriptase-polymerase chain reaction (RT-PCR) and the quantitative variant (qRT-PCR) have been the gold standard for COVID-19 diagnosis. However, faster antigen tests and other point-of-care (POC) devices have also played a significant role in containing the spread of SARS-CoV-2 by facilitating mass screening and delivering results in less time. Thus, despite the higher sensitivity and specificity of the RT-PCR assays, the impact of POC tests cannot be ignored. As a consequence, there has been an increased interest in the development of miniaturized, high-throughput, and automated PCR systems, many of which can be used at point-of-care. This review summarizes the recent advances in the development of miniaturized PCR systems with an emphasis on COVID-19 detection. The distinct features of digital PCR and electrochemical PCR are detailed along with the challenges. The potential of CRISPR/Cas technology for POC diagnostics is also highlighted. Commercial RT-PCR POC systems approved by various agencies for COVID-19 detection are discussed. Twit Text FOAVip Point-of-Care PCR Assays for COVID-19 Detection ????Biosensors (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34062874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34062874 #FOAvip English Wikipedia <ref>{{Cite pmid|34062874}}</ref> Point-of-Care PCR Assays for COVID-19 Detection #MMPMID34062874 Gupta N; Augustine S; Narayan T; O'Riordan A; Das A; Kumar D; Luong JHT; Malhotra BD Biosensors (Basel) 2021[May]; 11 (5): ä PMID34062874show ga Molecular diagnostics has been the front runner in the world's response to the COVID-19 pandemic. Particularly, reverse transcriptase-polymerase chain reaction (RT-PCR) and the quantitative variant (qRT-PCR) have been the gold standard for COVID-19 diagnosis. However, faster antigen tests and other point-of-care (POC) devices have also played a significant role in containing the spread of SARS-CoV-2 by facilitating mass screening and delivering results in less time. Thus, despite the higher sensitivity and specificity of the RT-PCR assays, the impact of POC tests cannot be ignored. As a consequence, there has been an increased interest in the development of miniaturized, high-throughput, and automated PCR systems, many of which can be used at point-of-care. This review summarizes the recent advances in the development of miniaturized PCR systems with an emphasis on COVID-19 detection. The distinct features of digital PCR and electrochemical PCR are detailed along with the challenges. The potential of CRISPR/Cas technology for POC diagnostics is also highlighted. Commercial RT-PCR POC systems approved by various agencies for COVID-19 detection are discussed. |*Point-of-Care Testing[MESH] |Animals[MESH] |COVID-19 Nucleic Acid Testing/*instrumentation/methods[MESH] |COVID-19/*diagnosis[MESH] |CRISPR-Cas Systems[MESH] |Equipment Design[MESH] |Humans[MESH] |Polymerase Chain Reaction/*instrumentation/methods[MESH]Point-of-Care PCR Assays for COVID-19 Detection (epmc).pdf DeepDyve Pubget Overpricing