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10.1002/jmv.27117 http://scihub22266oqcxt.onion/10.1002/jmv.27117 34061377!ä!34061377 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (10): 5825-5832 Nephropedia Template TP {{tp|p=34061377|t=2021. Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca(2+) -dependent membrane fusion |pdf=|usr=}}{{34061377}} gab.com Text Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca(2+) -dependent membrane fusion JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=34061377 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapeutics against the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and also against other pathogenic coronaviruses. In this study, we report on a kind of bisbenzylisoquinoline alkaloid, neferine, as a pan-coronavirus entry inhibitor. Neferine effectively protected HEK293/hACE2 and HuH7 cell lines from infection by different coronaviruses pseudovirus particles (SARS-CoV-2, SARS-CoV-2 [D614G, N501Y/D614G, 501Y.V1, 501Y.V2, 501Y.V3 variants], SARS-CoV, MERS-CoV) in vitro, with median effect concentration (EC(50) ) of 0.13-0.41 muM. Neferine blocked host calcium channels, thus inhibiting Ca(2+) -dependent membrane fusion and suppressing virus entry. This study provides experimental data to support the fact that neferine may be a promising lead for pan-coronaviruses therapeutic drug development. Twit Text FOAVip Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca(2+) -dependent membrane fusion ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=34061377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34061377 #FOAvip English Wikipedia <ref>{{Cite pmid|34061377}}</ref> Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca(2+) -dependent membrane fusion #MMPMID34061377 Yang Y; Yang P; Huang C; Wu Y; Zhou Z; Wang X; Wang S J Med Virol 2021[Oct]; 93 (10): 5825-5832 PMID34061377show ga The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapeutics against the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and also against other pathogenic coronaviruses. In this study, we report on a kind of bisbenzylisoquinoline alkaloid, neferine, as a pan-coronavirus entry inhibitor. Neferine effectively protected HEK293/hACE2 and HuH7 cell lines from infection by different coronaviruses pseudovirus particles (SARS-CoV-2, SARS-CoV-2 [D614G, N501Y/D614G, 501Y.V1, 501Y.V2, 501Y.V3 variants], SARS-CoV, MERS-CoV) in vitro, with median effect concentration (EC(50) ) of 0.13-0.41 muM. Neferine blocked host calcium channels, thus inhibiting Ca(2+) -dependent membrane fusion and suppressing virus entry. This study provides experimental data to support the fact that neferine may be a promising lead for pan-coronaviruses therapeutic drug development. |Antiviral Agents/*pharmacology[MESH] |Benzylisoquinolines/*pharmacology[MESH] |COVID-19/virology[MESH] |Calcium/*metabolism[MESH] |Cell Line[MESH] |Coronavirus/drug effects/physiology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Isoquinolines/pharmacology[MESH] |Phenols/pharmacology[MESH] |SARS-CoV-2/*drug effects/physiology[MESH]Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca(2(epmc).pdf DeepDyve Pubget Overpricing