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10.1111/bph.15579 http://scihub22266oqcxt.onion/10.1111/bph.15579 34061355!8239596!34061355     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2021 ; 178 (19): 3864-3868 Nephropedia Template TP {{tp|p=34061355|t=2021. Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19 |pdf=|usr=}}{{34061355}} gab.com Text Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19 JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34061355 #FOAvip Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive, and there are no treatments that reverse the pathophysiological effects of sepsis. Vitamin C has antioxidant, anti-inflammatory, anticoagulant and immune modulatory actions, so it is a rational treatment for sepsis. Here, we summarise data that support the use of megadose vitamin C as a treatment for sepsis and COVID-19. Megadose intravenous sodium ascorbate (150 g per 40 kg over 7 h) dramatically improved the clinical state and cardiovascular, pulmonary, hepatic and renal function and decreased body temperature, in a clinically relevant ovine model of Gram-negative bacteria-induced sepsis. In a critically ill COVID-19 patient, intravenous sodium ascorbate (60 g) restored arterial pressure, improved renal function and increased arterial blood oxygen levels. These findings suggest that megadose vitamin C should be trialled as a treatment for sepsis and COVID-19. Twit Text FOAVip Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19 ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34061355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34061355 #FOAvip English Wikipedia <ref>{{Cite pmid|34061355}}</ref> Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19 #MMPMID34061355 May CN; Bellomo R; Lankadeva YR Br J Pharmacol 2021[Oct]; 178 (19): 3864-3868 PMID34061355show ga Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive, and there are no treatments that reverse the pathophysiological effects of sepsis. Vitamin C has antioxidant, anti-inflammatory, anticoagulant and immune modulatory actions, so it is a rational treatment for sepsis. Here, we summarise data that support the use of megadose vitamin C as a treatment for sepsis and COVID-19. Megadose intravenous sodium ascorbate (150 g per 40 kg over 7 h) dramatically improved the clinical state and cardiovascular, pulmonary, hepatic and renal function and decreased body temperature, in a clinically relevant ovine model of Gram-negative bacteria-induced sepsis. In a critically ill COVID-19 patient, intravenous sodium ascorbate (60 g) restored arterial pressure, improved renal function and increased arterial blood oxygen levels. These findings suggest that megadose vitamin C should be trialled as a treatment for sepsis and COVID-19. |*COVID-19[MESH] |*Sepsis/drug therapy[MESH] |Animals[MESH] |Ascorbic Acid[MESH] |Humans[MESH] |Multiple Organ Failure/drug therapy[MESH] |SARS-CoV-2[MESH]Therapeutic potential of megadose vitamin C to reverse organ dysfuncti(epmc).pdf DeepDyve Pubget Overpricing