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10.1111/cei.13627 http://scihub22266oqcxt.onion/10.1111/cei.13627 34061349!8239517!34061349     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2021 ; 205 (3): 363-378 Nephropedia Template TP {{tp|p=34061349|t=2021. Human CD4(+) T cells specific for dominant epitopes of SARS-CoV-2 Spike and Nucleocapsid proteins with therapeutic potential |pdf=|usr=}}{{34061349}} gab.com Text Human CD4(+) T cells specific for dominant epitopes of SARS-CoV-2 Spike and Nucleocapsid proteins with therapeutic potential JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34061349 #FOAvip Since December 2019, Coronavirus disease-19 (COVID-19) has spread rapidly throughout the world, leading to a global effort to develop vaccines and treatments. Despite extensive progress, there remains a need for treatments to bolster the immune responses in infected immunocompromised individuals, such as cancer patients who recently underwent a haematopoietic stem cell transplantation. Immunological protection against COVID-19 is mediated by both short-lived neutralizing antibodies and long-lasting virus-reactive T cells. Therefore, we propose that T cell therapy may augment efficacy of current treatments. For the greatest efficacy with minimal adverse effects, it is important that any cellular therapy is designed to be as specific and directed as possible. Here, we identify T cells from COVID-19 patients with a potentially protective response to two major antigens of the SARS-CoV-2 virus, Spike and Nucleocapsid protein. By generating clones of highly virus-reactive CD4(+) T cells, we were able to confirm a set of nine immunodominant epitopes and characterize T cell responses against these. Accordingly, the sensitivity of T cell clones for their specific epitope, as well as the extent and focus of their cytokine response was examined. Moreover, using an advanced T cell receptor (TCR) sequencing approach, we determined the paired TCR-alphabeta sequences of clones of interest. While these data on a limited population require further expansion for universal application, the results presented here form a crucial first step towards TCR-transgenic CD4(+) T cell therapy of COVID-19. Twit Text FOAVip Human CD4(+) T cells specific for dominant epitopes of SARS-CoV-2 Spike and Nucleocapsid proteins with therapeutic potential ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34061349 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34061349 #FOAvip English Wikipedia <ref>{{Cite pmid|34061349}}</ref> Human CD4(+) T cells specific for dominant epitopes of SARS-CoV-2 Spike and Nucleocapsid proteins with therapeutic potential #MMPMID34061349 Verhagen J; van der Meijden ED; Lang V; Kremer AE; Volkl S; Mackensen A; Aigner M; Kremer AN Clin Exp Immunol 2021[Sep]; 205 (3): 363-378 PMID34061349show ga Since December 2019, Coronavirus disease-19 (COVID-19) has spread rapidly throughout the world, leading to a global effort to develop vaccines and treatments. Despite extensive progress, there remains a need for treatments to bolster the immune responses in infected immunocompromised individuals, such as cancer patients who recently underwent a haematopoietic stem cell transplantation. Immunological protection against COVID-19 is mediated by both short-lived neutralizing antibodies and long-lasting virus-reactive T cells. Therefore, we propose that T cell therapy may augment efficacy of current treatments. For the greatest efficacy with minimal adverse effects, it is important that any cellular therapy is designed to be as specific and directed as possible. Here, we identify T cells from COVID-19 patients with a potentially protective response to two major antigens of the SARS-CoV-2 virus, Spike and Nucleocapsid protein. By generating clones of highly virus-reactive CD4(+) T cells, we were able to confirm a set of nine immunodominant epitopes and characterize T cell responses against these. Accordingly, the sensitivity of T cell clones for their specific epitope, as well as the extent and focus of their cytokine response was examined. Moreover, using an advanced T cell receptor (TCR) sequencing approach, we determined the paired TCR-alphabeta sequences of clones of interest. While these data on a limited population require further expansion for universal application, the results presented here form a crucial first step towards TCR-transgenic CD4(+) T cell therapy of COVID-19. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Amino Acid Sequence[MESH] |CD4-Positive T-Lymphocytes/*immunology/*virology[MESH] |CD8-Positive T-Lymphocytes/immunology/virology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/*immunology/*therapy/virology[MESH] |Clone Cells/immunology/virology[MESH] |Coronavirus Nucleocapsid Proteins/chemistry/genetics/*immunology[MESH] |Cytokines/biosynthesis[MESH] |Epitopes, T-Lymphocyte/chemistry/genetics/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Immunodominant Epitopes/chemistry/genetics/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Phosphoproteins/chemistry/genetics/immunology[MESH] |Receptors, Antigen, T-Cell, alpha-beta/genetics/immunology[MESH] |SARS-CoV-2/chemistry/genetics/*immunology[MESH]Human CD4(+) T cells specific for dominant epitopes of SARS-CoV-2 Spik(epmc).pdf DeepDyve Pubget Overpricing