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10.1172/JCI147201 http://scihub22266oqcxt.onion/10.1172/JCI147201 34060490!8266207!34060490     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (11): ä Nephropedia Template TP {{tp|p=34060490|t=2021. Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D |pdf=|usr=}}{{34060490}} gab.com Text Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34060490 #FOAvip Worse outcomes occur in aged compared with young populations after infections with respiratory viruses, including pathogenic coronaviruses (SARS-CoV, MERS-CoV, and SARS-CoV-2), and are associated with a suboptimal lung milieu ("inflammaging"). We previously showed that a single inducible phospholipase, PLA2G2D, is associated with a proresolving/antiinflammatory response in the lungs, and increases with age. Survival was increased in naive Pla2g2d-/- mice infected with SARS-CoV resulting from augmented respiratory dendritic cell (rDC) activation and enhanced priming of virus-specific T cells. Here, in contrast, we show that intranasal immunization provided no additional protection in middle-aged Pla2g2d-/- mice infected with any of the 3 pathogenic human coronaviruses because virtually no virus-specific antibodies or follicular helper CD4+ T (Tfh) cells were produced. Using MERS-CoV-infected mice, we found that these effects did not result from T or B cell intrinsic factors. Rather, they resulted from enhanced, and ultimately, pathogenic rDC activation, as manifested most prominently by enhanced IL-1beta expression. Wild-type rDC transfer to Pla2g2d-/- mice in conjunction with partial IL-1beta blockade reversed this defect and resulted in increased virus-specific antibody and Tfh responses. Together, these results indicate that PLA2G2D has an unexpected role in the lungs, serving as an important modulator of rDC activation, with protective and pathogenic effects in respiratory coronavirus infections and immunization, respectively. Twit Text FOAVip Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34060490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34060490 #FOAvip English Wikipedia <ref>{{Cite pmid|34060490}}</ref> Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D #MMPMID34060490 Zheng J; Meyerholz D; Wong LR; Gelb M; Murakami M; Perlman S J Clin Invest 2021[Jun]; 131 (11): ä PMID34060490show ga Worse outcomes occur in aged compared with young populations after infections with respiratory viruses, including pathogenic coronaviruses (SARS-CoV, MERS-CoV, and SARS-CoV-2), and are associated with a suboptimal lung milieu ("inflammaging"). We previously showed that a single inducible phospholipase, PLA2G2D, is associated with a proresolving/antiinflammatory response in the lungs, and increases with age. Survival was increased in naive Pla2g2d-/- mice infected with SARS-CoV resulting from augmented respiratory dendritic cell (rDC) activation and enhanced priming of virus-specific T cells. Here, in contrast, we show that intranasal immunization provided no additional protection in middle-aged Pla2g2d-/- mice infected with any of the 3 pathogenic human coronaviruses because virtually no virus-specific antibodies or follicular helper CD4+ T (Tfh) cells were produced. Using MERS-CoV-infected mice, we found that these effects did not result from T or B cell intrinsic factors. Rather, they resulted from enhanced, and ultimately, pathogenic rDC activation, as manifested most prominently by enhanced IL-1beta expression. Wild-type rDC transfer to Pla2g2d-/- mice in conjunction with partial IL-1beta blockade reversed this defect and resulted in increased virus-specific antibody and Tfh responses. Together, these results indicate that PLA2G2D has an unexpected role in the lungs, serving as an important modulator of rDC activation, with protective and pathogenic effects in respiratory coronavirus infections and immunization, respectively. |*Antibody Formation[MESH] |Animals[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/enzymology/genetics/*immunology[MESH] |Chlorocebus aethiops[MESH] |Group II Phospholipases A2/deficiency/*immunology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Middle East Respiratory Syndrome Coronavirus/*immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Severe Acute Respiratory Syndrome/enzymology/genetics/*immunology[MESH] |Severe acute respiratory syndrome-related coronavirus/*immunology[MESH]Coronavirus-specific antibody production in middle-aged mice requires (epmc).pdf DeepDyve Pubget Overpricing