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10.1038/s41467-021-23482-5 http://scihub22266oqcxt.onion/10.1038/s41467-021-23482-5 34059671!8167181!34059671     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34059671&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 3256 Nephropedia Template TP {{tp|p=34059671|t=2021. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing |pdf=|usr=}}{{34059671}} gab.com Text Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34059671 #FOAvip Macrophages perform diverse functions within tissues during immune responses to pathogens and injury, but molecular mechanisms by which physical properties of the tissue regulate macrophage behavior are less well understood. Here, we examine the role of the mechanically activated cation channel Piezo1 in macrophage polarization and sensing of microenvironmental stiffness. We show that macrophages lacking Piezo1 exhibit reduced inflammation and enhanced wound healing responses. Additionally, macrophages expressing the transgenic Ca(2+) reporter, Salsa6f, reveal that Ca(2+) influx is dependent on Piezo1, modulated by soluble signals, and enhanced on stiff substrates. Furthermore, stiffness-dependent changes in macrophage function, both in vitro and in response to subcutaneous implantation of biomaterials in vivo, require Piezo1. Finally, we show that positive feedback between Piezo1 and actin drives macrophage activation. Together, our studies reveal that Piezo1 is a mechanosensor of stiffness in macrophages, and that its activity modulates polarization responses. Twit Text FOAVip Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34059671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34059671 #FOAvip English Wikipedia <ref>{{Cite pmid|34059671}}</ref> Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing #MMPMID34059671 Atcha H; Jairaman A; Holt JR; Meli VS; Nagalla RR; Veerasubramanian PK; Brumm KT; Lim HE; Othy S; Cahalan MD; Pathak MM; Liu WF Nat Commun 2021[May]; 12 (1): 3256 PMID34059671show ga Macrophages perform diverse functions within tissues during immune responses to pathogens and injury, but molecular mechanisms by which physical properties of the tissue regulate macrophage behavior are less well understood. Here, we examine the role of the mechanically activated cation channel Piezo1 in macrophage polarization and sensing of microenvironmental stiffness. We show that macrophages lacking Piezo1 exhibit reduced inflammation and enhanced wound healing responses. Additionally, macrophages expressing the transgenic Ca(2+) reporter, Salsa6f, reveal that Ca(2+) influx is dependent on Piezo1, modulated by soluble signals, and enhanced on stiff substrates. Furthermore, stiffness-dependent changes in macrophage function, both in vitro and in response to subcutaneous implantation of biomaterials in vivo, require Piezo1. Finally, we show that positive feedback between Piezo1 and actin drives macrophage activation. Together, our studies reveal that Piezo1 is a mechanosensor of stiffness in macrophages, and that its activity modulates polarization responses. |Actins/metabolism[MESH] |Animals[MESH] |Biocompatible Materials/*adverse effects[MESH] |Cells, Cultured[MESH] |Cellular Microenvironment/immunology[MESH] |Disease Models, Animal[MESH] |Feedback, Physiological[MESH] |Female[MESH] |Foreign-Body Reaction/*immunology[MESH] |Humans[MESH] |Ion Channels/genetics/*metabolism[MESH] |Macrophage Activation[MESH] |Macrophages/*immunology/metabolism[MESH] |Male[MESH] |Mechanotransduction, Cellular/immunology[MESH] |Mice[MESH] |Primary Cell Culture[MESH] |Subcutaneous Tissue/surgery[MESH]Mechanically activated ion channel Piezo1 modulates macrophage polariz(epmc).pdf DeepDyve Pubget Overpricing