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10.1038/s41392-021-00634-z http://scihub22266oqcxt.onion/10.1038/s41392-021-00634-z 34059617!8165147!34059617     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Signal+Transduct+Target+Ther 2021 ; 6 (1): 213 Nephropedia Template TP {{tp|p=34059617|t=2021. A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity |pdf=|usr=}}{{34059617}} gab.com Text A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity JO: Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=34059617 #FOAvip Although inoculation of COVID-19 vaccines has rolled out globally, there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries. Here, we report on the development of a highly efficacious mRNA vaccine, SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core-shell structured lipopolyplex (LPP) nanoparticles. SW0123 is easy to produce using a large-scale microfluidics-based apparatus. The unique core-shell structured nanoparticle facilitates vaccine uptake and demonstrates a high colloidal stability, and a desirable biodistribution pattern with low liver targeting effect upon intramuscular administration. Extensive evaluations in mice and nonhuman primates revealed strong immunogenicity of SW0123, represented by induction of Th1-polarized T cell responses and high levels of antibodies that were capable of neutralizing not only the wild-type SARS-CoV-2, but also a panel of variants including D614G and N501Y variants. In addition, SW0123 conferred effective protection in both mice and non-human primates upon SARS-CoV-2 challenge. Taken together, SW0123 is a promising vaccine candidate that holds prospects for further evaluation in humans. Twit Text FOAVip A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity ????Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=34059617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34059617 #FOAvip English Wikipedia <ref>{{Cite pmid|34059617}}</ref> A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity #MMPMID34059617 Yang R; Deng Y; Huang B; Huang L; Lin A; Li Y; Wang W; Liu J; Lu S; Zhan Z; Wang Y; A R; Wang W; Niu P; Zhao L; Li S; Ma X; Zhang L; Zhang Y; Yao W; Liang X; Zhao J; Liu Z; Peng X; Li H; Tan W Signal Transduct Target Ther 2021[May]; 6 (1): 213 PMID34059617show ga Although inoculation of COVID-19 vaccines has rolled out globally, there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries. Here, we report on the development of a highly efficacious mRNA vaccine, SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core-shell structured lipopolyplex (LPP) nanoparticles. SW0123 is easy to produce using a large-scale microfluidics-based apparatus. The unique core-shell structured nanoparticle facilitates vaccine uptake and demonstrates a high colloidal stability, and a desirable biodistribution pattern with low liver targeting effect upon intramuscular administration. Extensive evaluations in mice and nonhuman primates revealed strong immunogenicity of SW0123, represented by induction of Th1-polarized T cell responses and high levels of antibodies that were capable of neutralizing not only the wild-type SARS-CoV-2, but also a panel of variants including D614G and N501Y variants. In addition, SW0123 conferred effective protection in both mice and non-human primates upon SARS-CoV-2 challenge. Taken together, SW0123 is a promising vaccine candidate that holds prospects for further evaluation in humans. |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19 Vaccines/*immunology/therapeutic use[MESH] |COVID-19/*immunology/prevention & control/virology[MESH] |Female[MESH] |Humans[MESH] |Immunogenicity, Vaccine/immunology[MESH] |Lymphocyte Activation/immunology[MESH] |Mice[MESH] |SARS-CoV-2/*immunology/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/antagonists & inhibitors/*immunology[MESH] |Th1 Cells/immunology/virology[MESH] |Vaccines, Synthetic/immunology/therapeutic use[MESH] |Viral Vaccines/immunology[MESH]A core-shell structured COVID-19 mRNA vaccine with favorable biodistri(epmc).pdf DeepDyve Pubget Overpricing