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10.1016/j.vaccine.2021.05.047

http://scihub22266oqcxt.onion/10.1016/j.vaccine.2021.05.047
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34059373!8133612!34059373
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suck abstract from ncbi


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pmid34059373      Vaccine 2021 ; 39 (28): 3724-3730
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  • The first Chinese national standards for SARS-CoV-2 neutralizing antibody #MMPMID34059373
  • Guan L; Yu Y; Wu X; Nie J; Zhang J; Wang Z; Li N; Shi R; Zhao H; Chen H; Luo C; Hu Y; Wang Y; Huang W; Xu M; Hou J
  • Vaccine 2021[Jun]; 39 (28): 3724-3730 PMID34059373show ga
  • In order to meet the domestic urgent needs of evaluating the immunogenicity of vaccines and the potency testing of therapeutic antibody products against coronavirus disease 2019 (COVID-19), the first Chinese national standards for SARS-CoV-2 neutralizing antibody were established. The potency and stability of the candidate standards were determined by neutralization assay and accelerated degradation study. The stability studies showed that the standards were stable in the short-term. The collaborative study showed that the candidate standards could reduce the variations in neutralization titers between labs and thus improve comparability of neutralizing antibody measurements. Sample 22 has been approved by the Biological Product Reference Standards Sub-Committee of the National Drug Reference Standards Committee as the first Chinese National Standard for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) neutralizing antibody, with an assigned potency of 1,000 units per milliliter (U/ml). This standard will contribute to the standardized assessment of the quality and efficacy of vaccines and therapeutics for COVID-19 in China.
  • |*Antibodies, Neutralizing[MESH]
  • |*COVID-19[MESH]
  • |Antibodies, Viral[MESH]
  • |China[MESH]
  • |Humans[MESH]
  • |Neutralization Tests[MESH]
  • |Reference Standards[MESH]
  • |SARS-CoV-2[MESH]


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