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10.1186/s10020-021-00317-z http://scihub22266oqcxt.onion/10.1186/s10020-021-00317-z 34058986!8165337!34058986     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Med 2021 ; 27 (1): 54 Nephropedia Template TP {{tp|p=34058986|t=2021. Heterologous vaccine interventions: boosting immunity against future pandemics |pdf=|usr=}}{{34058986}} gab.com Text Heterologous vaccine interventions: boosting immunity against future pandemics JO: Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34058986 #FOAvip While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens. The best-known non-specific effects from an unrelated or heterologous vaccine are from the use of the Bacillus Calmette-Guerin (BCG) vaccine, mediated partly through trained immunity. Other vaccines have similar heterologous effects. This review covers molecular mechanisms behind the heterologous effects, and the potential use of heterologous vaccination in the current COVID-19 pandemic. We then discuss novel pandemic response strategies based on rapidly deployed, widespread heterologous vaccination to boost population-level immunity for initial, partial protection against infection and/or clinical disease, while specific vaccines are developed. Twit Text FOAVip Heterologous vaccine interventions: boosting immunity against future pandemics ????Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34058986 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34058986 #FOAvip English Wikipedia <ref>{{Cite pmid|34058986}}</ref> Heterologous vaccine interventions: boosting immunity against future pandemics #MMPMID34058986 Marin-Hernandez D; Nixon DF; Hupert N Mol Med 2021[May]; 27 (1): 54 PMID34058986show ga While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens. The best-known non-specific effects from an unrelated or heterologous vaccine are from the use of the Bacillus Calmette-Guerin (BCG) vaccine, mediated partly through trained immunity. Other vaccines have similar heterologous effects. This review covers molecular mechanisms behind the heterologous effects, and the potential use of heterologous vaccination in the current COVID-19 pandemic. We then discuss novel pandemic response strategies based on rapidly deployed, widespread heterologous vaccination to boost population-level immunity for initial, partial protection against infection and/or clinical disease, while specific vaccines are developed. |*Pandemics[MESH] |BCG Vaccine/*immunology/therapeutic use[MESH] |COVID-19/immunology/*prevention & control/virology[MESH] |Humans[MESH] |Immunity, Heterologous/immunology[MESH] |SARS-CoV-2/immunology/pathogenicity[MESH]Heterologous vaccine interventions: boosting immunity against future p(epmc).pdf DeepDyve Pubget Overpricing