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10.1016/j.tox.2021.152822 http://scihub22266oqcxt.onion/10.1016/j.tox.2021.152822 34058295!8161735!34058295     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicology 2021 ; 458 (ä): 152822 Nephropedia Template TP {{tp|p=34058295|t=2021. Computational and experimental studies on the inhibitory mechanism of hydroxychloroquine on hERG |pdf=|usr=}}{{34058295}} gab.com Text Computational and experimental studies on the inhibitory mechanism of hydroxychloroquine on hERG JO: Toxicology http://www.kidney.de/pget.php?&tw=1&pmid=34058295 #FOAvip Hydroxychloroquine (HCQ) was noted to produce severe cardiac arrhythmia, an adverse effect as its use against severe acute respiratory syndrome caused by coronavirus 2 (SAES-CoV-2). HCQ is an antimalarial drug with quinoline structure. Some other quinoline compounds, such as fluoroquinolone antibiotics (FQs), also lead to arrhythmias characterized by QT prolongation. QT prolongation is usually related to the human ether-a-go-go-related gene (hERG) potassium channel inhibitory activity of most drugs. In this research, molecular docking was used to study the potential inhibitory activities of HCQ as well as other quinolines derivatives and hERG potassium channel protein. The possible causes of these QT prolongation effects were revealed. Molecular docking and patch clamp experiments showed that HCQ could bind to hERG and inhibit the efflux of potassium ion preferentially in the repolarization stage. The IC(50) of HCQ was 8.6 muM +/- 0.8 muM. FQs, which are quinoline derivatives, could also bind to hERG molecules. The binding energies of FQs varied according to their molecular polarity. It was found that drugs with a quinoline structure, particularly with high molecular polarity, can exert a significant potential hERG inhibitory activity. The potential side effects of QT prolongation during the development and use of quinolines should be carefully considered. Twit Text FOAVip Computational and experimental studies on the inhibitory mechanism of hydroxychloroquine on hERG ????Toxicology http://www.kidney.de/pget.php?&tw=1&pmid=34058295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34058295 #FOAvip English Wikipedia <ref>{{Cite pmid|34058295}}</ref> Computational and experimental studies on the inhibitory mechanism of hydroxychloroquine on hERG #MMPMID34058295 Yu R; Li P Toxicology 2021[Jun]; 458 (ä): 152822 PMID34058295show ga Hydroxychloroquine (HCQ) was noted to produce severe cardiac arrhythmia, an adverse effect as its use against severe acute respiratory syndrome caused by coronavirus 2 (SAES-CoV-2). HCQ is an antimalarial drug with quinoline structure. Some other quinoline compounds, such as fluoroquinolone antibiotics (FQs), also lead to arrhythmias characterized by QT prolongation. QT prolongation is usually related to the human ether-a-go-go-related gene (hERG) potassium channel inhibitory activity of most drugs. In this research, molecular docking was used to study the potential inhibitory activities of HCQ as well as other quinolines derivatives and hERG potassium channel protein. The possible causes of these QT prolongation effects were revealed. Molecular docking and patch clamp experiments showed that HCQ could bind to hERG and inhibit the efflux of potassium ion preferentially in the repolarization stage. The IC(50) of HCQ was 8.6 muM +/- 0.8 muM. FQs, which are quinoline derivatives, could also bind to hERG molecules. The binding energies of FQs varied according to their molecular polarity. It was found that drugs with a quinoline structure, particularly with high molecular polarity, can exert a significant potential hERG inhibitory activity. The potential side effects of QT prolongation during the development and use of quinolines should be carefully considered. |Amino Acids/chemistry[MESH] |Computational Biology[MESH] |Ether-A-Go-Go Potassium Channels/*antagonists & inhibitors/chemistry/drug effects[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Hydroxychloroquine/chemistry/*pharmacology[MESH] |Inhibitory Concentration 50[MESH] |Molecular Docking Simulation[MESH]Computational and experimental studies on the inhibitory mechanism of (epmc).pdf DeepDyve Pubget Overpricing