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10.1002/JLB.4COVHR0221-093RR http://scihub22266oqcxt.onion/10.1002/JLB.4COVHR0221-093RR 34057760!8242921!34057760     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Leukoc+Biol 2022 ; 111 (2): 497-508 Nephropedia Template TP {{tp|p=34057760|t=2022. Inflammasome regulation in driving COVID-19 severity in humans and immune tolerance in bats |pdf=|usr=}}{{34057760}} gab.com Text Inflammasome regulation in driving COVID-19 severity in humans and immune tolerance in bats JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=34057760 #FOAvip Coronaviruses (CoVs) are RNA viruses that cause human respiratory infections. Zoonotic transmission of the SARS-CoV-2 virus caused the recent COVID-19 pandemic, which led to over 2 million deaths worldwide. Elevated inflammatory responses and cytotoxicity in the lungs are associated with COVID-19 severity in SARS-CoV-2-infected individuals. Bats, which host pathogenic CoVs, operate dampened inflammatory responses and show tolerance to these viruses with mild clinical symptoms. Delineating the mechanisms governing these host-specific inflammatory responses is essential to understand host-virus interactions determining the outcome of pathogenic CoV infections. Here, we describe the essential role of inflammasome activation in determining COVID-19 severity in humans and innate immune tolerance in bats that host several pathogenic CoVs. We further discuss mechanisms leading to inflammasome activation in human SARS-CoV-2 infection and how bats are molecularly adapted to suppress these inflammasome responses. We also report an analysis of functionally important residues of inflammasome components that provide new clues of bat strategies to suppress inflammasome signaling and innate immune responses. As spillover of bat viruses may cause the emergence of new human disease outbreaks, the inflammasome regulation in bats and humans likely provides specific strategies to combat the pathogenic CoV infections. Twit Text FOAVip Inflammasome regulation in driving COVID-19 severity in humans and immune tolerance in bats ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=34057760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34057760 #FOAvip English Wikipedia <ref>{{Cite pmid|34057760}}</ref> Inflammasome regulation in driving COVID-19 severity in humans and immune tolerance in bats #MMPMID34057760 Nagaraja S; Jain D; Kesavardhana S J Leukoc Biol 2022[Feb]; 111 (2): 497-508 PMID34057760show ga Coronaviruses (CoVs) are RNA viruses that cause human respiratory infections. Zoonotic transmission of the SARS-CoV-2 virus caused the recent COVID-19 pandemic, which led to over 2 million deaths worldwide. Elevated inflammatory responses and cytotoxicity in the lungs are associated with COVID-19 severity in SARS-CoV-2-infected individuals. Bats, which host pathogenic CoVs, operate dampened inflammatory responses and show tolerance to these viruses with mild clinical symptoms. Delineating the mechanisms governing these host-specific inflammatory responses is essential to understand host-virus interactions determining the outcome of pathogenic CoV infections. Here, we describe the essential role of inflammasome activation in determining COVID-19 severity in humans and innate immune tolerance in bats that host several pathogenic CoVs. We further discuss mechanisms leading to inflammasome activation in human SARS-CoV-2 infection and how bats are molecularly adapted to suppress these inflammasome responses. We also report an analysis of functionally important residues of inflammasome components that provide new clues of bat strategies to suppress inflammasome signaling and innate immune responses. As spillover of bat viruses may cause the emergence of new human disease outbreaks, the inflammasome regulation in bats and humans likely provides specific strategies to combat the pathogenic CoV infections. |*Immune Tolerance[MESH] |*Immunity, Innate[MESH] |Animals[MESH] |COVID-19/immunology/*pathology/virology[MESH] |Chiroptera[MESH] |Humans[MESH] |Inflammasomes/*immunology/metabolism[MESH] |Phylogeny[MESH]Inflammasome regulation in driving COVID-19 severity in humans and imm(epmc).pdf DeepDyve Pubget Overpricing