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10.1093/ndt/gfab193

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34057463!8195197!34057463
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suck abstract from ncbi


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pmid34057463      Nephrol+Dial+Transplant 2021 ; 36 (9): 1704-1709
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  • High immunogenicity of a messenger RNA-based vaccine against SARS-CoV-2 in chronic dialysis patients #MMPMID34057463
  • Longlune N; Nogier MB; Miedouge M; Gabilan C; Cartou C; Seigneuric B; Del Bello A; Marion O; Faguer S; Izopet J; Kamar N
  • Nephrol Dial Transplant 2021[Aug]; 36 (9): 1704-1709 PMID34057463show ga
  • BACKGROUND: Patients with chronic kidney disease, dialysis patients and kidney transplant patients are at high risk of developing severe coronavirus disease 2019 (COVID-19). Data regarding the immunogenicity of anti-severe acute respiratory syndrome coronavirus 2 messenger RNA (anti-SARS-CoV-2 mRNA) vaccines in dialysis patients were published recently. We assessed the immunogenicity of anti-SARS-CoV-2 mRNA vaccine in dialysis patients. PATIENTS AND METHODS: One hundred and nine patients on haemodialysis (n = 85) or peritoneal dialysis (n = 24) have received two injections of 30-mug doses of BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) that were administered intramuscularly 28 days apart. Those who were still seronegative after the second dose were given a third dose 1 month later. Anti-SARS-CoV-2 antibodies were tested before and after vaccination. RESULTS: Ninety-one out of the 102 patients who had at least a 1-month follow-up after the second (n = 97) or the third (n = 5) vaccine doses had anti-SARS-CoV-2 antibodies. The seroconversion rate was 88.7% (86 out of 97 patients) among SARS-CoV-2 seronegative patients at the initiation of vaccination. Receiving immunosuppressive therapy was an independent predictive factor for non-response to vaccination. CONCLUSION: Due to high immunogenicity and safety of mRNA vaccines, we strongly recommend prioritizing a two-dose vaccination of dialysis patients. A third dose can be required in non-responders to two doses. When possible, patients waiting for a kidney transplantation should be offered the vaccine before transplantation.
  • |*COVID-19 Vaccines/immunology[MESH]
  • |*COVID-19/prevention & control[MESH]
  • |*Immunogenicity, Vaccine[MESH]
  • |*Renal Dialysis[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |BNT162 Vaccine[MESH]
  • |Humans[MESH]
  • |Vaccines, Synthetic/immunology[MESH]


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