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10.1002/acr.24716

http://scihub22266oqcxt.onion/10.1002/acr.24716
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34057311!8212085!34057311
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suck abstract from ncbi

pmid34057311      Arthritis+Care+Res+(Hoboken) 2022 ; 74 (11): 1780-1785
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  • Isolation, Behavioral Changes, and Low Seroprevalence of SARS-CoV-2 Antibodies in Patients With Systemic Lupus Erythematosus or Rheumatoid Arthritis #MMPMID34057311
  • Ammitzboll C; Andersen JB; Vils SR; Mistegaard CE; Mikkelsen S; Erikstrup C; Thomsen MK; Hauge EM; Troldborg A
  • Arthritis Care Res (Hoboken) 2022[Nov]; 74 (11): 1780-1785 PMID34057311show ga
  • OBJECTIVE: Patients with chronic rheumatic diseases (CRDs), such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), require special attention during the COVID-19 pandemic as they are considered at risk of severe infections. Our objective was to assess the seroprevalence of SARS-CoV-2 in patients with SLE and RA and to assess patient behavior, disease-related symptoms, and mental health. METHODS: More than 900 participants were included: 405 patients with RA or SLE (CRD patients) and 513 blood donors. All participants had blood SARS-CoV-2 total antibodies measured (sensitivity 96.7%, specificity 99.5%) and answered a questionnaire concerning behavior, anxiety, and symptoms of depression (Patient Health Questionnaire 9). The CRD patients were further asked about physical activity, adherence to medication, and disease-related symptoms. RESULTS: CRD patients had a significantly lower seroprevalence of SARS-CoV-2 antibodies (n = 1 of 365, 0.3%) compared to blood donors (n = 10 of 513, 1.9%; P = 0.03). Almost 60% of patients were unable to exercise as usual, and increased pain and disease activity was experienced by 34% and 24% of patients, respectively. Almost 10% of patients reduced or discontinued their immunosuppressive treatments at their own initiative. Symptoms of moderate depression were present in 19% of patients compared to 6.8% of blood donors (P < 0.001). CONCLUSION: Low seroprevalence in patients with CRDs indicates successful mitigation of exposure to SARS-CoV-2. However, this mitigation appears to occur at the expense of physical activity, experience of increased pain, disease activity, and symptoms of depression. There is a need for care providers to be aware of these negative side effects and for further studies to investigate the possible long-term consequences.
  • |*Arthritis, Rheumatoid/diagnosis/epidemiology/psychology[MESH]
  • |*COVID-19/epidemiology[MESH]
  • |*Lupus Erythematosus, Systemic/diagnosis/epidemiology/drug therapy[MESH]
  • |Humans[MESH]
  • |Pain[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]


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