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10.1016/j.xcrm.2021.100313 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100313 34056628!8139315!34056628     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (6): 100313 Nephropedia Template TP {{tp|p=34056628|t=2021. Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions |pdf=|usr=}}{{34056628}} gab.com Text Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34056628 #FOAvip The continual emergence of novel coronaviruses (CoV), such as severe acute respiratory syndrome-(SARS)-CoV-2, highlights the critical need for broadly reactive therapeutics and vaccines against this family of viruses. From a recovered SARS-CoV donor sample, we identify and characterize a panel of six monoclonal antibodies that cross-react with CoV spike (S) proteins from the highly pathogenic SARS-CoV and SARS-CoV-2, and demonstrate a spectrum of reactivity against other CoVs. Epitope mapping reveals that these antibodies recognize multiple epitopes on SARS-CoV-2 S, including the receptor-binding domain, the N-terminal domain, and the S2 subunit. Functional characterization demonstrates that the antibodies mediate phagocytosis-and in some cases trogocytosis-but not neutralization in vitro. When tested in vivo in murine models, two of the antibodies demonstrate a reduction in hemorrhagic pathology in the lungs. The identification of cross-reactive epitopes recognized by functional antibodies expands the repertoire of targets for pan-coronavirus vaccine design strategies. Twit Text FOAVip Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34056628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34056628 #FOAvip English Wikipedia <ref>{{Cite pmid|34056628}}</ref> Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions #MMPMID34056628 Shiakolas AR; Kramer KJ; Wrapp D; Richardson SI; Schafer A; Wall S; Wang N; Janowska K; Pilewski KA; Venkat R; Parks R; Manamela NP; Raju N; Fechter EF; Holt CM; Suryadevara N; Chen RE; Martinez DR; Nargi RS; Sutton RE; Ledgerwood JE; Graham BS; Diamond MS; Haynes BF; Acharya P; Carnahan RH; Crowe JE Jr; Baric RS; Morris L; McLellan JS; Georgiev IS Cell Rep Med 2021[Jun]; 2 (6): 100313 PMID34056628show ga The continual emergence of novel coronaviruses (CoV), such as severe acute respiratory syndrome-(SARS)-CoV-2, highlights the critical need for broadly reactive therapeutics and vaccines against this family of viruses. From a recovered SARS-CoV donor sample, we identify and characterize a panel of six monoclonal antibodies that cross-react with CoV spike (S) proteins from the highly pathogenic SARS-CoV and SARS-CoV-2, and demonstrate a spectrum of reactivity against other CoVs. Epitope mapping reveals that these antibodies recognize multiple epitopes on SARS-CoV-2 S, including the receptor-binding domain, the N-terminal domain, and the S2 subunit. Functional characterization demonstrates that the antibodies mediate phagocytosis-and in some cases trogocytosis-but not neutralization in vitro. When tested in vivo in murine models, two of the antibodies demonstrate a reduction in hemorrhagic pathology in the lungs. The identification of cross-reactive epitopes recognized by functional antibodies expands the repertoire of targets for pan-coronavirus vaccine design strategies. |Animals[MESH] |Antibodies, Monoclonal/*immunology[MESH] |Antigen-Antibody Reactions[MESH] |B-Lymphocytes/cytology/metabolism[MESH] |COVID-19/pathology/virology[MESH] |Cell Line[MESH] |Cross Reactions/immunology[MESH] |Epitope Mapping[MESH] |Epitopes/*immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin Fc Fragments/immunology/*metabolism[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Phagocytosis[MESH] |Protein Subunits/immunology[MESH] |SARS-CoV-2/isolation & purification/metabolism[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology/metabolism[MESH]Cross-reactive coronavirus antibodies with diverse epitope specificiti(epmc).pdf DeepDyve Pubget Overpricing