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10.1016/j.medin.2021.02.007 http://scihub22266oqcxt.onion/10.1016/j.medin.2021.02.007 34054173!7914021!34054173     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Intensiva+(Engl+Ed) 2021 ; 45 (5): 261-270 Nephropedia Template TP {{tp|p=34054173|t=2021. Histopathological features in fatal COVID-19 acute respiratory distress syndrome |pdf=|usr=}}{{34054173}} gab.com Text Histopathological features in fatal COVID-19 acute respiratory distress syndrome JO: Med Intensiva (Engl Ed) http://www.kidney.de/pget.php?&tw=1&pmid=34054173 #FOAvip BACKGROUND: COVID-19 acute respiratory distress syndrome (ARDS) shares the common histological hallmarks with other forms of ARDS. However, the chronology of the histological lesions has not been well established. OBJECTIVE: To describe the chronological histopathological alterations in the lungs of patients with COVID-19 related ARDS. DESIGN: A prospective cohort study was carried out. SETTING: Intensive Care Unit of a tertiary hospital. PATIENTS: The first 22 consecutive COVID-19 deaths. MEASUREMENTS: Lung biopsies and histopathological analyses were performed in deceased patients with COVID-19 related ARDS. Clinical data and patient course were evaluated. RESULTS: The median patient age was 66 [63-74] years; 73% were males. The median duration of mechanical ventilation was 17 [8-24] days. COVID-19 induced pulmonary injury was characterized by an exudative phase in the first week of the disease, followed by a proliferative/organizing phase in the second and third weeks, and finally an end-stage fibrosis phase after the third week. Viral RNA and proteins were detected in pneumocytes and macrophages in a very early stage of the disease, and were no longer detected after the second week. LIMITATION: Limited sample size. CONCLUSIONS: The chronological evolution of COVID-19 lung histopathological lesions seems to be similar to that seen in other forms of ARDS. In particular, lung lesions consistent with potentially corticosteroid-sensitive lesions are seen. Twit Text FOAVip Histopathological features in fatal COVID-19 acute respiratory distress syndrome ????Med Intensiva (Engl Ed) http://www.kidney.de/pget.php?&tw=1&pmid=34054173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34054173 #FOAvip English Wikipedia <ref>{{Cite pmid|34054173}}</ref> Histopathological features in fatal COVID-19 acute respiratory distress syndrome #MMPMID34054173 Merdji H; Mayeur S; Schenck M; Oulehri W; Clere-Jehl R; Cunat S; Herbrecht JE; Janssen-Langenstein R; Nicolae A; Helms J; Meziani F; Chenard MP Med Intensiva (Engl Ed) 2021[Jun]; 45 (5): 261-270 PMID34054173show ga BACKGROUND: COVID-19 acute respiratory distress syndrome (ARDS) shares the common histological hallmarks with other forms of ARDS. However, the chronology of the histological lesions has not been well established. OBJECTIVE: To describe the chronological histopathological alterations in the lungs of patients with COVID-19 related ARDS. DESIGN: A prospective cohort study was carried out. SETTING: Intensive Care Unit of a tertiary hospital. PATIENTS: The first 22 consecutive COVID-19 deaths. MEASUREMENTS: Lung biopsies and histopathological analyses were performed in deceased patients with COVID-19 related ARDS. Clinical data and patient course were evaluated. RESULTS: The median patient age was 66 [63-74] years; 73% were males. The median duration of mechanical ventilation was 17 [8-24] days. COVID-19 induced pulmonary injury was characterized by an exudative phase in the first week of the disease, followed by a proliferative/organizing phase in the second and third weeks, and finally an end-stage fibrosis phase after the third week. Viral RNA and proteins were detected in pneumocytes and macrophages in a very early stage of the disease, and were no longer detected after the second week. LIMITATION: Limited sample size. CONCLUSIONS: The chronological evolution of COVID-19 lung histopathological lesions seems to be similar to that seen in other forms of ARDS. In particular, lung lesions consistent with potentially corticosteroid-sensitive lesions are seen. äHistopathological features in fatal COVID-19 acute respiratory distres(epmc).pdf DeepDyve Pubget Overpricing