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10.4049/jimmunol.2100135 http://scihub22266oqcxt.onion/10.4049/jimmunol.2100135 34049971!8627528!34049971     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2021 ; 206 (12): 2785-2790 Nephropedia Template TP {{tp|p=34049971|t=2021. Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19 |pdf=|usr=}}{{34049971}} gab.com Text Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34049971 #FOAvip Protective immunity against COVID-19 likely depends on the production of SARS-CoV-2-specific plasma cells and memory B cells postinfection or postvaccination. Previous work has found that germinal center reactions are disrupted in severe COVID-19. This may adversely affect long-term immunity against reinfection. Consistent with an extrafollicular B cell response, patients with severe COVID-19 have elevated frequencies of clonally expanded, class-switched, unmutated plasmablasts. However, it is unclear whether B cell populations in individuals with mild COVID-19 are similarly skewed. In this study, we use single-cell RNA sequencing of B cells to show that in contrast to patients with severe COVID-19, subjects with mildly symptomatic COVID-19 have B cell repertoires enriched for clonally diverse, somatically hypermutated memory B cells approximately 30 d after the onset of symptoms. This provides evidence that B cell responses are less disrupted in mild COVID-19 and result in the production of memory B cells. Twit Text FOAVip Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34049971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34049971 #FOAvip English Wikipedia <ref>{{Cite pmid|34049971}}</ref> Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19 #MMPMID34049971 Hoehn KB; Ramanathan P; Unterman A; Sumida TS; Asashima H; Hafler DA; Kaminski N; Dela Cruz CS; Sealfon SC; Bukreyev A; Kleinstein SH J Immunol 2021[Jun]; 206 (12): 2785-2790 PMID34049971show ga Protective immunity against COVID-19 likely depends on the production of SARS-CoV-2-specific plasma cells and memory B cells postinfection or postvaccination. Previous work has found that germinal center reactions are disrupted in severe COVID-19. This may adversely affect long-term immunity against reinfection. Consistent with an extrafollicular B cell response, patients with severe COVID-19 have elevated frequencies of clonally expanded, class-switched, unmutated plasmablasts. However, it is unclear whether B cell populations in individuals with mild COVID-19 are similarly skewed. In this study, we use single-cell RNA sequencing of B cells to show that in contrast to patients with severe COVID-19, subjects with mildly symptomatic COVID-19 have B cell repertoires enriched for clonally diverse, somatically hypermutated memory B cells approximately 30 d after the onset of symptoms. This provides evidence that B cell responses are less disrupted in mild COVID-19 and result in the production of memory B cells. |B-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Cohort Studies[MESH] |Humans[MESH]Cutting Edge: Distinct B Cell Repertoires Characterize Patients with M(epmc).pdf DeepDyve Pubget Overpricing