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10.1126/sciadv.abg7156 http://scihub22266oqcxt.onion/10.1126/sciadv.abg7156 34049881!ä!34049881 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34049881&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2021 ; 7 (22): ä Nephropedia Template TP {{tp|p=34049881|t=2021. Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates |pdf=|usr=}}{{34049881}} gab.com Text Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34049881 #FOAvip Since the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), various vaccines are being developed, with most vaccine candidates focusing on the viral spike protein. Here, we developed a previously unknown subunit vaccine comprising the receptor binding domain (RBD) of the spike protein fused with the tetanus toxoid epitope P2 (RBD-P2) and tested its efficacy in rodents and nonhuman primates (NHPs). We also investigated whether the SARS-CoV-2 nucleocapsid protein (N) could increase vaccine efficacy. Immunization with N and RBD-P2 (RBDP2/N) + alum increased T cell responses in mice and neutralizing antibody levels in rats compared with those obtained using RBD-P2 + alum. Furthermore, in NHPs, RBD-P2/N + alum induced slightly faster SARS-CoV-2 clearance than that induced by RBD-P2 + alum, albeit without statistical significance. Our study supports further development of RBD-P2 as a vaccine candidate against SARS-CoV-2. Also, it provides insights regarding the use of N in protein-based vaccines against SARS-CoV-2. Twit Text FOAVip Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34049881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34049881 #FOAvip English Wikipedia <ref>{{Cite pmid|34049881}}</ref> Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates #MMPMID34049881 Hong SH; Oh H; Park YW; Kwak HW; Oh EY; Park HJ; Kang KW; Kim G; Koo BS; Hwang EH; Baek SH; Park HJ; Lee YS; Bang YJ; Kim JY; Bae SH; Lee SJ; Seo KW; Kim H; Kwon T; Kim JH; Lee S; Kim E; Kim Y; Park JH; Park SI; Goncalves M; Weon BM; Jeong H; Nam KT; Hwang KA; Kim J; Kim H; Lee SM; Hong JJ; Nam JH Sci Adv 2021[May]; 7 (22): ä PMID34049881show ga Since the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), various vaccines are being developed, with most vaccine candidates focusing on the viral spike protein. Here, we developed a previously unknown subunit vaccine comprising the receptor binding domain (RBD) of the spike protein fused with the tetanus toxoid epitope P2 (RBD-P2) and tested its efficacy in rodents and nonhuman primates (NHPs). We also investigated whether the SARS-CoV-2 nucleocapsid protein (N) could increase vaccine efficacy. Immunization with N and RBD-P2 (RBDP2/N) + alum increased T cell responses in mice and neutralizing antibody levels in rats compared with those obtained using RBD-P2 + alum. Furthermore, in NHPs, RBD-P2/N + alum induced slightly faster SARS-CoV-2 clearance than that induced by RBD-P2 + alum, albeit without statistical significance. Our study supports further development of RBD-P2 as a vaccine candidate against SARS-CoV-2. Also, it provides insights regarding the use of N in protein-based vaccines against SARS-CoV-2. |Animals[MESH] |COVID-19 Vaccines/genetics/*immunology[MESH] |COVID-19/genetics/immunology/*prevention & control[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Nucleocapsid Proteins/genetics/*immunology[MESH] |Female[MESH] |Macaca fascicularis[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Transgenic[MESH] |Phosphoproteins/genetics/immunology[MESH] |Protein Domains[MESH] |Rats[MESH] |Recombinant Fusion Proteins/genetics/*immunology[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Sf9 Cells[MESH] |Spike Glycoprotein, Coronavirus/genetics/*immunology[MESH] |Spodoptera[MESH] |Tetanus Toxoid/genetics/*immunology[MESH]Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman(epmc).pdf DeepDyve Pubget Overpricing