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10.1016/j.ebiom.2021.103403 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2021.103403 34049240!8143995!34049240     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34049240&cmd=llinks): Failed to open stream: HTTP request failed! 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Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters |pdf=|usr=}}{{34049240}} gab.com Text Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=34049240 #FOAvip BACKGROUND: Within one year after its emergence, more than 108 million people acquired SARS-CoV-2 and almost 2.4 million succumbed to COVID-19. New SARS-CoV-2 variants of concern (VoC) are emerging all over the world, with the threat of being more readily transmitted, being more virulent, or escaping naturally acquired and vaccine-induced immunity. At least three major prototypic VoC have been identified, i.e. the United Kingdom, UK (B.1.1.7), South African (B.1.351) and Brazilian (B.1.1.28.1) variants. These are replacing formerly dominant strains and sparking new COVID-19 epidemics. METHODS: We studied the effect of infection with prototypic VoC from both B.1.1.7 and B.1.351 variants in female Syrian golden hamsters to assess their relative infectivity and virulence in direct comparison to two basal SARS-CoV-2 strains isolated in early 2020. FINDINGS: A very efficient infection of the lower respiratory tract of hamsters by these VoC is observed. In line with clinical evidence from patients infected with these VoC, no major differences in disease outcome were observed as compared to the original strains as was quantified by (i) histological scoring, (ii) micro-computed tomography, and (iii) analysis of the expression profiles of selected antiviral and pro-inflammatory cytokine genes. Noteworthy however, in hamsters infected with VoC B.1.1.7, a particularly strong elevation of proinflammatory cytokines was detected. INTERPRETATION: We established relevant preclinical infection models that will be pivotal to assess the efficacy of current and future vaccine(s) (candidates) as well as therapeutics (small molecules and antibodies) against two important SARS-CoV-2 VoC. FUNDING: Stated in the acknowledgment. Twit Text FOAVip Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=34049240 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34049240 #FOAvip English Wikipedia <ref>{{Cite pmid|34049240}}</ref> Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters #MMPMID34049240 Abdelnabi R; Boudewijns R; Foo CS; Seldeslachts L; Sanchez-Felipe L; Zhang X; Delang L; Maes P; Kaptein SJF; Weynand B; Vande Velde G; Neyts J; Dallmeier K EBioMedicine 2021[Jun]; 68 (ä): 103403 PMID34049240show ga BACKGROUND: Within one year after its emergence, more than 108 million people acquired SARS-CoV-2 and almost 2.4 million succumbed to COVID-19. New SARS-CoV-2 variants of concern (VoC) are emerging all over the world, with the threat of being more readily transmitted, being more virulent, or escaping naturally acquired and vaccine-induced immunity. At least three major prototypic VoC have been identified, i.e. the United Kingdom, UK (B.1.1.7), South African (B.1.351) and Brazilian (B.1.1.28.1) variants. These are replacing formerly dominant strains and sparking new COVID-19 epidemics. METHODS: We studied the effect of infection with prototypic VoC from both B.1.1.7 and B.1.351 variants in female Syrian golden hamsters to assess their relative infectivity and virulence in direct comparison to two basal SARS-CoV-2 strains isolated in early 2020. FINDINGS: A very efficient infection of the lower respiratory tract of hamsters by these VoC is observed. In line with clinical evidence from patients infected with these VoC, no major differences in disease outcome were observed as compared to the original strains as was quantified by (i) histological scoring, (ii) micro-computed tomography, and (iii) analysis of the expression profiles of selected antiviral and pro-inflammatory cytokine genes. Noteworthy however, in hamsters infected with VoC B.1.1.7, a particularly strong elevation of proinflammatory cytokines was detected. INTERPRETATION: We established relevant preclinical infection models that will be pivotal to assess the efficacy of current and future vaccine(s) (candidates) as well as therapeutics (small molecules and antibodies) against two important SARS-CoV-2 VoC. FUNDING: Stated in the acknowledgment. |Animals[MESH] |COVID-19/diagnostic imaging/genetics/*pathology[MESH] |Cytokines/*genetics[MESH] |Disease Models, Animal[MESH] |Evolution, Molecular[MESH] |Female[MESH] |Gene Expression Profiling[MESH] |Gene Expression Regulation[MESH] |Mesocricetus[MESH] |Respiratory System/diagnostic imaging/pathology/*virology[MESH] |SARS-CoV-2/classification/immunology/*pathogenicity[MESH] |Virulence[MESH]Comparing infectivity and virulence of emerging SARS-CoV-2 variants in(epmc).pdf DeepDyve Pubget Overpricing