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10.1016/j.ijbiomac.2021.05.139

http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2021.05.139
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34048833!8144117!34048833
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suck abstract from ncbi


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pmid34048833      Int+J+Biol+Macromol 2021 ; 183 (ä): 1753-1773
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  • Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus #MMPMID34048833
  • Guo Y; Chen X; Gong P
  • Int J Biol Macromol 2021[Jul]; 183 (ä): 1753-1773 PMID34048833show ga
  • The deficiency of chemical-synthesized antiviral drugs when applied in clinical therapy, such as drug resistance, and the lack of effective antiviral drugs to treat some newly emerging virus infections, such as COVID-19, promote the demand of novelty and safety anti-virus drug candidate from natural functional ingredient. Numerous studies have shown that some polysaccharides sourcing from edible and medicinal fungus (EMFs) exert direct or indirect anti-viral capacities. However, the internal connection of fungus type, polysaccharides structural characteristics, action mechanism was still unclear. Herein, our review focus on the two aspects, on the one hand, we discussed the type of anti-viral EMFs and the structural characteristics of polysaccharides to clarify the structure-activity relationship, on the other hand, the directly or indirectly antiviral mechanism of EMFs polysaccharides, including virus function suppression, immune-modulatory activity, anti-inflammatory activity, regulation of population balance of gut microbiota have been concluded to provide a comprehensive theory basis for better clinical utilization of EMFs polysaccharides as anti-viral agents.
  • |*Anti-Inflammatory Agents/chemistry/classification/therapeutic use[MESH]
  • |*Antiviral Agents/chemistry/classification/therapeutic use[MESH]
  • |*COVID-19 Drug Treatment[MESH]
  • |*Fungal Polysaccharides/chemistry/classification/therapeutic use[MESH]
  • |*Immunologic Factors/chemistry/classification/therapeutic use[MESH]
  • |Agaricales/*chemistry[MESH]
  • |COVID-19/immunology/prevention & control[MESH]
  • |Gastrointestinal Microbiome/drug effects/immunology[MESH]
  • |Humans[MESH]


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