Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1039/d1cc01410b http://scihub22266oqcxt.onion/10.1039/d1cc01410b 34048518!ä!34048518 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Commun+(Camb) 2021 ; 57 (51): 6229-6232 Nephropedia Template TP {{tp|p=34048518|t=2021. Synthesis and characterisation of N-gene targeted NIR-II fluorescent probe for selective localisation of SARS-CoV-2 |pdf=|usr=}}{{34048518}} gab.com Text Synthesis and characterisation of N-gene targeted NIR-II fluorescent probe for selective localisation of SARS-CoV-2 JO: Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=34048518 #FOAvip Tracking the viral progression of SARS-CoV-2 in COVID-19 infected body tissues is an emerging need of the current pandemic. Imaging at near infrared second biological window (NIR-II) offers striking benefits over the other technologies to explore deep-tissue information. Here we design, synthesise and characterise a molecular probe that selectively targets the N-gene of SARS-CoV-2. Highly specific antisense oligonucleotides (ASOs) were conjugated to lead sulfide quantum dots using a UV-triggered thiol-ene click chemistry for the recognition of viral RNA. Our ex vivo imaging studies demonstrated that the probe exhibits aggregation induced NIR-II emission only in presence of SARS-CoV-2 RNA which can be attributed to the efficient hybridisation of the ASOs with their target RNA strands. Twit Text FOAVip Synthesis and characterisation of N-gene targeted NIR-II fluorescent probe for selective localisation of SARS-CoV-2 ????Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=34048518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34048518 #FOAvip English Wikipedia <ref>{{Cite pmid|34048518}}</ref> Synthesis and characterisation of N-gene targeted NIR-II fluorescent probe for selective localisation of SARS-CoV-2 #MMPMID34048518 Moitra P; Alafeef M; Dighe K; Sheffield Z; Dahal D; Pan D Chem Commun (Camb) 2021[Jun]; 57 (51): 6229-6232 PMID34048518show ga Tracking the viral progression of SARS-CoV-2 in COVID-19 infected body tissues is an emerging need of the current pandemic. Imaging at near infrared second biological window (NIR-II) offers striking benefits over the other technologies to explore deep-tissue information. Here we design, synthesise and characterise a molecular probe that selectively targets the N-gene of SARS-CoV-2. Highly specific antisense oligonucleotides (ASOs) were conjugated to lead sulfide quantum dots using a UV-triggered thiol-ene click chemistry for the recognition of viral RNA. Our ex vivo imaging studies demonstrated that the probe exhibits aggregation induced NIR-II emission only in presence of SARS-CoV-2 RNA which can be attributed to the efficient hybridisation of the ASOs with their target RNA strands. |Animals[MESH] |COVID-19/*diagnosis/diagnostic imaging/metabolism/*virology[MESH] |Click Chemistry/methods[MESH] |Fluorescent Dyes/chemical synthesis/*chemistry[MESH] |Humans[MESH] |Lung/diagnostic imaging/metabolism/virology[MESH] |Metal Nanoparticles/chemistry[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Models, Animal[MESH] |Oligonucleotides, Antisense/*chemistry[MESH] |Quantum Dots/*chemistry[MESH] |SARS-CoV-2/genetics/*isolation & purification/metabolism[MESH]Synthesis and characterisation of N-gene targeted NIR-II fluorescent p(epmc).pdf DeepDyve Pubget Overpricing